Preparation and in vitro characterization of dexamethasone-loaded poly(D,L-lactic acid) microspheres embedded in poly(ethylene glycol)-poly({varepsilon}-caprolactone)-poly(ethylene glycol) hydrogel for orthopedic tissue engineering

Journal of Biomaterials Applications
Min FanZhiYong Qian

Abstract

The corium is decreased to about half of its thickness in skin defects and wrinkles due to gravity and environment. In this study, dexamethasone/poly(d,l-lactic acid) (Mn = 160,000) microspheres were incorporated into poly(ethylene glycol)-poly(ε-caprolactone)-poly(ethylene glycol) (Mn = 3300) hydrogel to prepare an injectable hydrogel composite. The composite was designed to increase the thickness of the corium. Dexamethasone/poly(d,l-lactic acid) microspheres were prepared by oil-in-water emulsion/solvent evaporation technique. The properties of microspheres were investigated by size distribution measurement, scanning electron microscope and x-ray diffraction. Drug loading, encapsulation efficiency, and drug delivery behavior of microspheres were also studied in detail. Cell adhesion of microspheres was investigated by NIH3T3 cell in vitro. The properties of hydrogel composite were investigated by scanning electron microscope, rheological measurements and methyl thiazolyl tetrazolium assay. Drug release from composite was determined by HPLC-UV analysis. These results suggested that poly(d,l-lactic acid) microspheres encapsulating dexamethasone embedded in poly(ethylene glycol)-poly(ε-caprolactone)-poly(ethylene glycol) hydrog...Continue Reading

References

Jul 11, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cory BerklandDaniel W Pack
Jul 26, 2003·Pharmaceutical Research·Cory BerklandDaniel W Pack
Nov 19, 2003·AAPS PharmSciTech·Rassoul DinarvandFatemeh Atyabi
Dec 29, 2004·International Journal of Pharmaceutics·Myung-Kwan ChunHoo-Kyun Choi
Mar 5, 2005·Seminars in Cutaneous Medicine and Surgery·Didier Vochelle
Jan 19, 2006·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Danny Vleggaar
Apr 29, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Banu S ZolnikDiane J Burgess
May 11, 2006·Journal of Biomaterials Applications·Mark Walton, Nicholas J Cotton
Jun 21, 2006·Dermatologic Therapy·Adam M Rotunda, Rhoda S Narins
Aug 8, 2006·International Journal of Pharmaceutics·Tae Gwan Park, Hyuk Sang Yoo
Dec 13, 2006·International Journal of Pharmaceutics·Carolina Gómez-GaeteElias Fattal
Mar 21, 2007·Dermatologic Therapy·Tiffani K Hamilton
May 24, 2007·Plastic and Reconstructive Surgery·Pierre J Nicolau
Sep 17, 2008·International Journal of Pharmaceutics·ChangYang GongZhiYong Qian
Mar 17, 2009·Disease-a-month : DM·Shana Kusin, Jonathan Lippitz
Jan 18, 2011·Aesthetic Surgery Journal·Clark Friedrich Schierle, Laurie A Casas
Sep 6, 2011·International Journal of Pharmaceutics·Archana RawatDiane J Burgess

❮ Previous
Next ❯

Citations

Dec 11, 1999·Journal of Biomaterials Science. Polymer Edition·D LeckbandA Halperin
Feb 4, 2014·International Journal of Nanomedicine·RangRang FanGang Guo
Apr 29, 2014·International Journal of Pharmaceutics·Zhi-Yao HeZhi-Yong Qian
Nov 25, 2016·Journal of Biomaterials Applications·Engin PazarçevirenAyşen Tezcaner
Jun 5, 2018·Journal of Biomaterials Science. Polymer Edition·Junde GuoGuangneng Dong

❮ Previous
Next ❯

Methods Mentioned

BETA
x-ray diffraction

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.