Preparation and in vitro evaluation of doxorubicin-loaded Fe₃O₄ magnetic nanoparticles modified with biocompatible copolymers.

International Journal of Nanomedicine
Abolfazl AkbarzadehSoodabeh Davaran

Abstract

Superparamagnetic iron oxide nanoparticles are attractive materials that have been widely used in medicine for drug delivery, diagnostic imaging, and therapeutic applications. In our study, superparamagnetic iron oxide nanoparticles and the anticancer drug, doxorubicin hydrochloride, were encapsulated into poly (D, L-lactic-co-glycolic acid) poly (ethylene glycol) (PLGA-PEG) nanoparticles for local treatment. The magnetic properties conferred by superparamagnetic iron oxide nanoparticles could help to maintain the nanoparticles in the joint with an external magnet. A series of PLGA:PEG triblock copolymers were synthesized by ring-opening polymerization of D, L-lactide and glycolide with different molecular weights of polyethylene glycol (PEG(2000), PEG(3000), and PEG(4000)) as an initiator. The bulk properties of these copolymers were characterized using (1)H nuclear magnetic resonance spectroscopy, gel permeation chromatography, Fourier transform infrared spectroscopy, and differential scanning calorimetry. In addition, the resulting particles were characterized by x-ray powder diffraction, scanning electron microscopy, and vibrating sample magnetometry. The doxorubicin encapsulation amount was reduced for PLGA:PEG(2000) and P...Continue Reading

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Citations

Jan 25, 2013·Journal of Nanobiotechnology·Navin Kumar VermaYurii K Gun'ko
Aug 30, 2012·Nanoscale Research Letters·Alireza ValizadehSoodabeh Davaran
Feb 26, 2013·Nanoscale Research Letters·Abolfazl AkbarzadehKazem Nejati-Koshki
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Feb 6, 2018·Advanced Pharmaceutical Bulletin·Fatemeh SafariAli Mohammad Tamaddon
Feb 23, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Nahideh AsadiAbolfazl Akbarzadeh

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Methods Mentioned

BETA
nuclear
differential scanning calorimetry
scanning electron microscopy
x-ray diffraction

Software Mentioned

VEGA
TESCAN

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