Preparation and in vitro release of dual-drug resinates containing equivalent content dextromethorphan and diphenhydramine

Drug Development and Industrial Pharmacy
Prasert AkkaramongkolpornMitr Pathipvanich

Abstract

The dual-drug resinate containing equivalent content of dextromethorphan hydrobromide (DTM) and diphenhydramine hydrochloride (DPH) was developed and characterized. To achieve this specific resinate, a procedure of simultaneous dual-drug loading using loading solutions composed of different proportions of DTM and DPH was performed and a dual-drug loading diagram was constructed to determine the equivalent drug loading solution (ELS) and also the estimated equivalent drug content (EQC). The effects of resin crosslinkage, overall drug concentration of the loading solution, and temperature during drug loading on the values of ELS and EQC were assessed. The increased overall drug concentration from 0.25 to 1.0% w/v elevated the EQC values from 18 to 35% w/w for low crosslinked resins (Dowex 50 W x 2 and x 4), and from 18 to 27% w/w for high crosslinked resin (Dowex 50 W x 8). It also changed the values of ELS from 0.50 to 0.48 for the low crosslinked resins, and 0.50 to 0.55 for the high crosslinked resin. For the high crosslinked resin, the applied heat from 35 to 65 degrees C further increased the values of EQC from 27 to 32% w/w, and changed the values of ELS in the reverse direction from 0.55 to 0.48. However, the heat did not ...Continue Reading

References

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Citations

Oct 20, 2012·Drug Development and Industrial Pharmacy·Wipada SamprasitPraneet Opanasopit
Jul 27, 2010·Drug Development and Industrial Pharmacy·Huan-Xiang ZengWei-San Pan
Aug 4, 2007·Journal of Pharmaceutical Sciences·Beatrice AlbertiniLorenzo Rodriguez
Feb 6, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Wei XiaJianqi Zhu

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