Preparation and in vitro/in vivo characterization of curcumin microspheres intended to treat colon cancer.

Journal of Pharmacy & Bioallied Sciences
M MadhaviA V Jithan

Abstract

The objective of the present investigation was to prepare colon targeted curcumin microspheres using Eudragit S100 and evaluate the same for in vitro/in vivo properties. A "O/O solvent evaporation" technique was used in the preparation of microspheres. The influence of various process variables including stirring speed, drug:polymer ratio and percentage of emulsifier on the fabrication were investigated and the formulation was optimized. Prepared microspheres were evaluated for in vitro and in vivo properties. Surface morphology, particle size, percentage drug entrapment, percentage yield, drug polymer interaction, in vitro drug release in simulated gastrointestinal transit conditions and stability were the in vitro parameters investigated. Using an optimized formulation, drug release into the systemic circulation and organ distribution were investigated as in vivo parameters. In vivo parameters were estimated in male albino rats. Curcumin microspheres of Eudragit S100 were successfully prepared using o/o solvent evaporation method. Microspheres prepared using 1:2 drug:polymer ratio, with a stirring speed of 1000 rpm, and using 1.0% w/v concentration of emulsifying agent was selected as an optimized formulation. The release stu...Continue Reading

Citations

Oct 16, 2012·Journal of Drug Targeting·Arpit BhargavaPradyumna Kumar Mishra
Jan 19, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mina MehannySamar Mansour
Jun 13, 2014·Molecular Pharmaceutics·Elisa Panzarini, Luciana Dini
Mar 14, 2017·Nutrition and Cancer·Parasuraman Aiya SubramaniVenkata Ramireddy Narala
Jan 12, 2019·Critical Reviews in Food Science and Nutrition·Sita Sharan PatelPriyal Jain

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BETA
infrared spectroscopy

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