PMID: 1356952Jul 1, 1992

Preparation and in vivo binding of [11C]carazolol, a radiotracer for the beta-adrenergic receptor

International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
M S BerridgeJ M Vesselle

Abstract

Carazolol is a high affinity beta-adrenergic receptor antagonist which is relatively non-specific for the receptor subtypes. The labeling of the two enantiomers of this compound with carbon-11, including the synthesis of the required labeling precursors, is reported. The yield and specific activity are sufficient for use in positron tomography. Biodistribution and specific receptor binding studies show the labeled material to be of interest for further investigation as a radiopharmaceutical for positron tomography.

References

Jan 1, 1985·International Journal of Nuclear Medicine and Biology·R E GibsonR Eng
Sep 1, 1983·The Journal of Pharmacy and Pharmacology·B CostinJ C Wanstall
Nov 1, 1983·The International Journal of Applied Radiation and Isotopes·G BergerD Comar

Citations

May 25, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Philip H ElsingaWillem Vaalburg
May 9, 2000·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·T J VisserW Vaalburg
Nov 28, 2002·Nuclear Medicine and Biology·Héric ValetteDaniel Marzin
Jun 26, 1999·Nuclear Medicine and Biology·A R StudenovS Todde
Oct 1, 2003·Clinical Positron Imaging : Official Journal of the Institute for Clinical P.E.T·Philip H ElsingaWillem Vaalburg
Oct 27, 2007·Neurochemistry International·Aren van WaardePhilip H Elsinga

Related Concepts

Carazolol, monohydrochloride
Adrenergic beta-Antagonists
Carbon Radioisotopes
Intravenous Injections
Isotope Labeling, Stable
Propanolamines
Drug or Chemical Tissue Distribution

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