Preparation and in vivo evaluation of mucoadhesive microparticles containing amoxycillin-resin complexes for drug delivery to the gastric mucosa

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
M CuñaD Torres

Abstract

In this work, microparticles consisting of amoxycillin-loaded ion-exchange resin encapsulated in mucoadhesive polymers (polycarbophil and Carbopol 934) were prepared with the aim of increasing the efficacy of amoxycillin in the treatment of peptic ulcers by achieving targeted delivery to the gastric mucosa and prolonged drug release. An oil-in-oil solvent evaporation technique was conveniently modified in order to obtain polymer microparticles containing multiple amoxycillin-resin cores. Polycarbophil microparticles were spherical, Carbopol 934 microparticles irregular. In vitro release of amoxycillin was rapid with or without a polymer coating. Gastrointestinal transit in rats was investigated by fluorescence microscopy using particles loaded with fluorescein instead of amoxycillin: gastric residence time was longer, and the distribution of the particles on the mucosa apparently better, without any polymer coating.

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Citations

Mar 11, 2004·International Journal of Pharmaceutics·Manuel Tapia-Albarran, Leopoldo Villafuerte-Robles
May 20, 2003·International Journal of Pharmaceutics·Yasunori MiyazakiKozo Takayama
Dec 2, 2008·Chemical & Pharmaceutical Bulletin·Paruvathanahalli Siddalingam RajinikanthBrahmeshwar Mishra
Jun 5, 2010·Chemical & Pharmaceutical Bulletin·Surendra Ganeshlal GattaniVeena Shailendra Belgamwar
Apr 4, 2014·Journal of Advanced Pharmaceutical Technology & Research·Mohd Sajid AliKanhiya Lal Dhar
Jun 28, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Daniela LopesSalette Reis
Dec 25, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Sunil K JainAmrish Kumar
Jul 6, 2011·Journal of Microencapsulation·Adeola Adebisi, Barbara R Conway
Mar 2, 2006·Expert Opinion on Drug Delivery·Alexander StreubelRoland Bodmeier
Apr 3, 2013·Carbohydrate Polymers·Vipul D PrajapatiBhanu J Nagar
May 27, 2009·Drug Development and Industrial Pharmacy·Marie WahlgrenStefan Ulvenlund
Mar 10, 2017·Drug Development and Industrial Pharmacy·Jéssica Bassi da SilvaMarcos Luciano Bruschi
Jan 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhepeng LiuJun Pan
Dec 18, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nartaya ThirawongPornsak Sriamornsak
Nov 17, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·P S Rajinikanth, B Mishra
Mar 5, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiao-Lin ZhangJian-Fei Wang
Mar 18, 2021·Journal of Drug Targeting·Larissa SpósitoMarlus Chorilli

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