Preparation and isolation of isobenzofuran

Beilstein Journal of Organic Chemistry
Morten K Peters, Rainer Herges

Abstract

The synthesis, isolation and characterization of isobenzofuran are described in this publication. Isobenzofuran is of general interest in synthetic and physical organic chemistry because it is one of the most reactive dienes known. A number of synthetic pathways have been published which all suffer from disadvantages such as low yields and difficult purification. We present a synthetic pathway to prepare isobenzofuran in laboratory scale with high yields, from affordable, commercially available starting materials.

References

Dec 1, 1989·Current Opinion in Cell Biology·P Doherty, F S Walsh
Jul 30, 2015·Angewandte Chemie·Kevin M Arendt, Abigail G Doyle

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Citations

Jun 23, 2021·Journal of Labelled Compounds & Radiopharmaceuticals·Zhongjie XuZuming Hu
Dec 12, 2018·Organic Letters·Morten K PetersRainer Herges
May 1, 2019·Organic Letters·Sean R NorrisBrett VanVeller

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Methods Mentioned

BETA
column chromatography
NMR

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