Feb 11, 2020

Preparation and optimization of chitosan nanoparticles from discarded squilla (Carinosquilla multicarinata ) shells for the delivery of anti-inflammatory drug: Diclofenac

Journal of the Air & Waste Management Association
Akshad BaldeR A Nazeer

Abstract

Biological waste from marine sources is discarded into various water bodies which leads to dramatic increase in the water pollution near coastal areas. This animal waste consists of bioactive compounds such as fatty acids, amino acids and chitin which can be used in agricultural and pharmaceutical sectors. The aim of the current study was to extract chitosan (CS) from the discarded shells of Carinosquilla multicarinata andprepare anti-inflammatory drug diclofenac potassium (DP) encapsulated chitosan nanoparticles (DP-CSNPs). The CS was extracted, purified and physicochemical and morphological properties were characterized such as viscosity (1.44cPs), molecular weight (~57 kDa), degree of deacetylation (83%). The DP-CSNPs were prepared by ionic gelation of extracted chitosan with tripolyphosphate (TPP) anions by varying chitosan, TPP and drug concentrations. SEM imaging showed that DP-CSNPs were nano-sized (248 nm) along with small, spherical and uniformity in shape. The endothermic peak appeared at 180°C while performing the thermal analysis of DP-CSNPs by differential scanning calorimetry (DSC). The Loading capacity (LC) and encapsulation efficiency (EE) were determined for all combinations while maximum EE (79.42%), LC (42.08...Continue Reading

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Mentioned in this Paper

Dipyridamole
Triphosphate
Chitin
Morphological
Diagnostic Imaging
Shapes
Diclofenac Potassium
Viral Load Measurement
Study
Eutropis multicarinata

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