Abstract
In this study, we developed nano-fiber-based tablets with acetaminophen (AAP; LogPow=0.51) for controlled-release delivery systems and evaluated in vitro drug dissolution and in vivo pharmacokinetics in rats. Nano-fibers made from methacrylic acid copolymer S (MAC; EUDRAGIT S100) and containing AAP were prepared using a solvent-based electrospinning (ES) method. In vitro dissolution rate profiles of AAP showed tableting pressure-dependent decreases and pH-dependent increases. The results of tablet tracking by X-ray irradiation showed tablets based on MAC nano-fibers did not disintegrate in the upper intestinal lumen and had the properties of a long-term-acting tablet. In addition, the in vitro release profiles of AAP from nano-fiber tablets prepared by dissolving MAC with AAP (NFT), nano-fiber tablets prepared by adsorbing AAP to drug-free MAC nano-fibers (NFTadso), and tablets prepared by adsorbing half the amount of AAP to MAC nano-fibers containing the remaining amount of AAP (NFThalf) showed independent controlled-release aspects of AAP compared with physical mixture tablets (PMT). In vivo pharmacokinetic studies in rats after intraduodenal administration of 14 mg/rat AAP in NFT, NFTadso, and NFThalf demonstrated that all t...Continue Reading
References
Jun 23, 2007·Angewandte Chemie·Andreas Greiner, Joachim H Wendorff
Jan 27, 2010·Biotechnology Advances·Nandana Bhardwaj, Subhas C Kundu
Oct 5, 2010·Colloids and Surfaces. B, Biointerfaces·Chen HuangXiumei Mo
Nov 9, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Asako NishimuraNobuhito Shibata
Mar 5, 2013·The Analyst·Suwan N Jayasinghe
Aug 6, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Ana Paula Serafini ImmichJosé Antonio Tornero
Sep 24, 2013·Talanta·Theerasak RojanarataTanasait Ngawhirunpat
Jan 21, 2014·International Journal of Pharmaceutics·Mami HamoriNobuhito Shibata
Apr 29, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiuli HuXiabin Jing
Apr 29, 2014·International Journal of Biological Macromolecules·Rui ZhaoCe Wang
Dec 30, 2014·Colloids and Surfaces. B, Biointerfaces·Prasopchai TonglairoumPraneet Opanasopit
Mar 10, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Chan-Hee ParkCheol Sang Kim
Mar 10, 2015·Chemical & Pharmaceutical Bulletin·Mami HamoriNobuhito Shibata
May 13, 2015·Carbohydrate Polymers·Silvia Vaz Guerra NistaLucia Helena Innocentini Mei
Citations
Aug 4, 2018·Pharmaceutics·Gergő FülöpGyörgy Marosi
Dec 22, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Panna VassZsombor K Nagy
Apr 17, 2019·Nanomaterials·S M Shatil ShahriarYong-Kyu Lee
Dec 11, 2019·Pharmaceutics·Edina SzabóZsombor K Nagy
Jun 21, 2021·Advanced Drug Delivery Reviews·Muhammad Sohail ArshadKendal Pitt
Jun 13, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Edina SzabóZsombor K Nagy
Jun 21, 2018··Cho-Liang ChungSheng-Hung Shih