Preparation and Pharmacokinetics Evaluation of Solid Self-Microemulsifying Drug Delivery System (S-SMEDDS) of Osthole

AAPS PharmSciTech
Chaojie SunWenyou Fang

Abstract

The study was performed aiming to enhance the solubility and oral bioavailability of poorly water-soluble drug osthole by formulating solid self-microemulsifying drug delivery system (S-SMEDDS) via spherical crystallization technique. Firstly, the liquid self-microemulsifying drug delivery system (L-SMEDDS) of osthole was formulated with castor oil, Cremophor RH40, and 1,2-propylene glycol after screening various lipids and emulsifiers. The type and amount of polymeric materials, good solvents, bridging agents, and poor solvents in S-SMEDDS formulations were further determined by single-factor study. The optimal formulation contained 1:2 of ethyl cellulose (EC) and Eudragit S100, which served as matrix forming and enteric coating polymers respectively. Anhydrous ethanol and dichloromethane with a ratio of 5:3 are required to perform as good solvent and bridging agent, respectively, with the addition of 0.08% SDS aqueous solution as poor solvent. The optimized osthole S-SMEDDS had a high yield (83.91 ± 3.31%) and encapsulation efficiency (78.39 ± 2.25%). Secondly, osthole L-SMEDDS was solidified to osthole S-SMEDDS with no significant changes in terms of morphology, particle size, and zeta potential. In vitro release study demon...Continue Reading

References

Feb 25, 2000·Journal of Pharmaceutical Sciences·K KachrimanisS Malamataris
Jul 8, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Tao YiXiangliang Yang
Feb 25, 2009·Pharmaceutical Development and Technology·Maryam Maghsoodi, Masoud Esfahani
Mar 21, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Prabagar BalakrishnanHan-Gon Choi
Apr 22, 2009·AAPS PharmSciTech·Yogeshwar G Bachhav, Vandana B Patravale
Feb 26, 2010·Drug Development and Industrial Pharmacy·Maryam Maghsoodi, Fatemeh Sadeghpoor
Feb 26, 2010·AAPS PharmSciTech·Adhvait R DixitSamir G Patel
Feb 15, 2012·European Journal of Pharmacology·Fabio FusiSimona Saponara
Aug 27, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Namfa SermkaewRuedeekorn Wiwattanapatapee
May 27, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sharad MangalDavid A V Morton
Aug 8, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Zhong-Rong ZhangChun Wai Chan
Aug 20, 2016·Calcified Tissue International·Zhongrong ZhangChun Wai Chan
Aug 23, 2016·Cellular & Molecular Immunology·Tsan Sam Xiao
Aug 28, 2016·Journal of Ethnopharmacology·Guoqiang JiangWeiling Li
Apr 14, 2017·International Journal of Pharmaceutical Investigation·Arindam ChatterjeeBirendra Srivastava

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Citations

Oct 28, 2019·AAPS PharmSciTech·Sharel Rency D Almeida, Vamshi Krishna Tippavajhala
Apr 23, 2020·Pharmaceutics·Heejun ParkMin-Soo Kim
Feb 9, 2020·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Dilpreet SinghNeena Bedi
Feb 29, 2020·Anti-cancer Agents in Medicinal Chemistry·Milad AshrafizadehAmirhossein Sahebkar
Nov 12, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sevgi Güngör, Emine Kahraman
Mar 3, 2021·Drug Development and Industrial Pharmacy·Ling LinYanyu Xiao
Aug 14, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Indrani MajiPankaj Kumar Singh
Sep 25, 2021·Journal of the Science of Food and Agriculture·Chunmei WeiJiangnan Yu

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Methods Mentioned

BETA
solubility studies

Software Mentioned

DAS

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