Preparation and properties of EDC/NHS mediated crosslinking poly (gamma-glutamic acid)/epsilon-polylysine hydrogels

Materials Science & Engineering. C, Materials for Biological Applications
Jiachuan HuaChangsheng Qiao

Abstract

In this paper, a novel pH-sensitive poly (amino acid) hydrogel based on poly γ-glutamic acid (γ-PGA) and ε-polylysine (ε-PL) was prepared by carbodiimide (EDC) and N-hydroxysuccinimide (NHS) mediated polymerization. The influence of PGA/PL molar ratio and EDC/NHS concentration on the structure and properties was studied. Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS) proved that hydrogels were crosslinked through amide bond linkage, and the conversion rate of a carboxyl group could reach 96%. Scanning electron microscopy (SEM) results showed a regularly porous structure with 20 μm pore size in average. The gelation time in the crosslink process of PGA/PL hydrogels was within less than 5 min. PGA/PL hydrogels had excellent optical performance that was evaluated by a novel optotype method. Furthermore, PGA/PL hydrogels were found to be pH-sensitive, which could be adjusted to the pH of swelling media intelligently. The terminal pH of swelling medium could be controlled at 5 ± 1 after equilibrium when the initial pH was within 3-11. The swelling kinetics was found to follow a Voigt model in deionized water but a pseudo-second-order model in normal saline and phosphate buffer solution, re...Continue Reading

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Citations

Oct 11, 2016·Journal of Environmental Radioactivity·Shigeki Sakamoto, Yoshinori Kawase
Apr 21, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Qiao ZhangNianguo Dong
Aug 11, 2020·Engineering in Life Sciences·Nadja RadchenkovaMargarita S Kambourova
Sep 24, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mengting YinWenjie Zhang
Jul 3, 2019·Nanomaterials·Celia NietoEva M Martín Del Valle
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Veronica SanchezCarlos Angulo
Feb 19, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ang LiJinglong Yan
Mar 7, 2021·Carbohydrate Polymers·Jiachuan HuaBin Fei
Aug 19, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Bo LiuBo Jiang
Apr 4, 2021·Polymers·Jonathan David HinchliffeIpsita Roy
May 26, 2021·Regenerative Medicine·Farzaneh AavaniAbolfazl Nazbar
Jun 3, 2021·Polymers·Sinith WithanageElena Krivoshapkina
Jul 24, 2021·International Journal of Biological Macromolecules·Xiaoxue WangBo Chi
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Jul 27, 2018·ACS Applied Materials & Interfaces·Anbharasi VanangamudiXing Yang
Sep 15, 2021·Molecular Pharmaceutics·Saeed ManouchehriJoshua D Ramsey

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