Preparation and spectral investigation of inclusion complex of caffeic acid with hydroxypropyl-beta-cyclodextrin

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Min ZhangJianbin Chao

Abstract

The inclusion complexation behavior of caffeic acid (CA) with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was studied by UV-vis, fluorescence spectroscopy and nuclear magnetic resonance spectroscopy (NMR). Experimental conditions including the concentration of HP-beta-CD and media acidity were investigated in detail. The result suggested HP-beta-CD was more suitable for including CA in acidity solution. The binding contants (K) of the inclusion complexes were determined by linear regression analysis and the inclusion ratio was found to be 1:1. The water solubility of CA was increased by inclusion with HP-beta-CD according to the phase-solubility diagram. The spatial configuration of complex has been proposed based on (1)H NMR and two-dimensional (2D) NMR, the result suggested that CA was entrapped inside the hydrophobic core of HP-beta-CD with the lipophilic aromatic ring and the portion of ethylene.

References

Jun 6, 2000·Advanced Drug Delivery Reviews·F Hirayama, K Uekama

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Citations

Nov 25, 2014·Therapeutic Delivery·Eva PinhoGraça Soares
Oct 8, 2015·Journal of Microencapsulation·Eva PinhoMariana Henriques
Dec 5, 2013·Carbohydrate Polymers·Seyed Mohammad Taghi GharibzahediMohammad Mousavi
Dec 5, 2013·Carbohydrate Polymers·Eva PinhoMariana Henriques
Nov 26, 2011·International Journal of Biological Macromolecules·Jianbin ChaoLiwei Zhang
Dec 7, 2013·Journal of Agricultural and Food Chemistry·Marcos García-PadialArantza Zornoza
May 27, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Jianbin ChaoBingtai Zhang
Oct 10, 2014·Beilstein Journal of Organic Chemistry·Miriana KfourySophie Fourmentin
Jun 10, 2020·Expert Opinion on Drug Delivery·Sathiyabama Rajiv GandhiLucindo José Quintans Júnior
Apr 7, 2020·Journal of Biomolecular Structure & Dynamics·Ioannis AndreadelisThomas Mavromoustakos
Oct 23, 2019·International Journal of Molecular Sciences·Pascual García-PérezCarlos Bravo-Díaz

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