PMID: 8597779Nov 24, 1995Paper

Preparation and stability testing of a hydrogel for topical analgesia

Pharmacy World & Science : PWS
Y L NortierJ H Beijnen

Abstract

With the commercial availability of a cream (EMLA) containing a eutectic mixture of local anaesthetics, 2.5% (w/w) lidocaine and 2.5% (w/w) prilocaine, effective topical anaesthesia of the intact skin is possible without the need for subcutaneous injections or exposure to high concentrations of local anaesthetics. In our hospital a topical anaesthetic product was designed for the same purpose. The home-made product contains a eutectic mixture of a local anaesthetic (5% w/w) and l-menthol (1% w/w). Prilocaine was used as the local anaesthetic because it is known for its safety and its well investigated analgesic effects. The eutectic mixture of prilocaine and l-menthol was mixed with a carbopol hydrogel (1% w/w). Preliminary testing of this anaesthetic hydrogel in our hospital has yielded satisfactory results. The anaesthetic hydrogel was found to be stable after at least 3 months' storage at ambient temperature.

References

Aug 1, 1990·Contact Dermatitis·R J BlackW C Strang
Jan 1, 1989·British Journal of Anaesthesia·S Coley
Mar 1, 1985·British Journal of Anaesthesia·B HallénA Uppfeldt
Mar 1, 1994·Anesthesia and Analgesia·N M GajrajM F Watcha
Apr 1, 1994·Contact Dermatitis·J van den HoveJ M Lachapelle
Jan 1, 1994·Contact Dermatitis·S M Wilkinson, M H Beck
Jan 1, 1994·Contact Dermatitis·A AguirreJ L Díaz-Pérez
Jan 1, 1993·The Laryngoscope·V N CarrascoW P Biggers

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Citations

Nov 15, 2008·Biomedical Microdevices·Yuya MorimotoShoji Takeuchi
Nov 4, 2000·International Journal of Pharmaceutics·L KangJ W McCall
Jun 27, 1998·The Journal of Pharmacy and Pharmacology·C ValentaA Bernkop-Schnürch
Apr 13, 2010·International Journal of Pharmaceutics·Sarah FialaMarc B Brown

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