PMID: 11337147May 5, 2001Paper

Preparation, characterisation and photosensitivity studies of solid dispersions of diflunisal and Eudragit RS100 and RL100

International Journal of Pharmaceutics
R PignatelloG Puglisi

Abstract

Solid dispersions of diflunisal (DIF) with Eudragit RS100 (RS) and RL100 (RL) with different drug-to-polymer ratios were prepared by a solvent method (coevaporates) and were characterised in the solid state in comparison with the corresponding physical mixtures. The work was aimed at characterising the interactions occurring between DIF and RS or RL polymers, along with their influence on the in-vitro drug-dissolution pattern. The findings suggest that the drug did not change its crystalline form within the polymer network. Drug dispersion in the polymer matrix strongly influences its dissolution rate, which appears slower and more gradual while increasing the polymer ratios. Moreover, DIF is known to be a photosensitive compound, and its photoproduct has been found to be a toxic agent. This can be evidenced by testing red blood cell membranes for their resistance to the osmotic shock induced by UVA irradiation in the presence of DIF. The presence of some DIF/RS coevaporates was shown to reduce significantly the drug photosensitization process towards cell membranes. This suggests the possibility of combining the design of a drug delivery system with a photoprotective strategy.

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Citations

Sep 5, 2003·International Journal of Pharmaceutics·Hannele Eerikäinen, Esko I Kauppinen
Jul 5, 2006·Chemical & Pharmaceutical Bulletin·Richer ChenKazumi Danjo
Jul 4, 2012·International Journal of Molecular Sciences·Daode HuYaping Zhao
Jan 1, 2008·Indian Journal of Pharmaceutical Sciences·H N ShivakumarG Deshmukh
Apr 28, 2004·Drug Development and Industrial Pharmacy·Rosario PignatelloGiovanni Puglisi
Oct 30, 2012·Expert Opinion on Drug Delivery·Seema ThakralDipak K Majumdar
Apr 26, 2012·Expert Opinion on Drug Delivery·Ebru Başaran, Yasemin Yazan
Jul 10, 2013·Journal of Microencapsulation·Ebru BaşaranYasemin Yazan
May 1, 2010·Pharmaceutical Development and Technology·Ghassan Z AbdullahAzmin M Noor
Apr 22, 2008·Journal of Pharmaceutical Sciences·E VegaM A Egea
Aug 6, 2019·Advanced Pharmaceutical Bulletin·Khosro AdibkiaMohammad Barzegar-Jalali
Jun 17, 2020·Pharmaceutical Development and Technology·Nuha I Abou ObaidMohd A Alam
Oct 3, 2018·Advanced Functional Materials·Bernhard J MuellerRuslan I Dmitriev
Mar 21, 2006·Pharmaceutical Development and Technology·S SuttiruengwongP J Jansens
Sep 15, 2017·AAPS PharmSciTech·Karthik Yadav JangaS Narasimha Murthy
Feb 19, 2010·Pharmaceutical Development and Technology·Omaima A SammourAyman G Mowafy

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