Preparation, characterization and antimicrobial activity of inclusion complex of biochanin A with (2-hydroxypropyl)-β-cyclodextrin

The Journal of Pharmacy and Pharmacology
Ivana Lj NikolicIvana M Savic-Gajic

Abstract

An inclusion complex of biochanin A (BCA) with (2-hydroxypropyl)-β-cyclodextrin (HP-β-CD) was prepared in the ethanol solution to improve its water solubility. Using the FTIR, 1 H-NMR, XRD, DSC and SEM methods, the structural characterization of the prepared complex was analysed. The phase-solubility study has shown that the solubility of BCA was increased twofold in 42% (v/v) ethanol solution after complexation with HP-β-CD. The complex between BCA and HP-β-CD was prepared in the molar ratio of 1 : 1. The antibacterial activity of the inclusion complex was investigated against the various bacteria, fungus and yeast using the microdilution method. The minimal inhibitory concentration values for the analysed strain of bacteria were in the range of 0.84-1.69 mg/cm3 , whereby the prepared inclusion complex exhibited less effect on the reduction of the number of Escherichia coli and Klebsiella pneumoniae species compared to pure BCA. The inclusion complex of BCA was significantly more active against Candida albicans than pure BCA. Biochanin A and its inclusion complex has not expressed the activity against Aspergillus niger. Based on the obtained results, it can be concluded that the antimicrobial activity of BCA was remained uncha...Continue Reading

References

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Citations

Feb 6, 2019·International Journal of Molecular Sciences·Simone Braga CarneiroÁdley Antonini Neves de Lima
Jul 30, 2019·Frontiers in Pharmacology·Chen YuYang Wang
Dec 13, 2019·Expert Opinion on Drug Discovery·Ivana M Savić-Gajić, Ivan M Savić
Dec 29, 2020·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Vimalasruthi NarayananStalin Thambusamy

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