Preparation, characterization and utilization of coreshell super paramagnetic iron oxide nanoparticles for curcumin delivery

PloS One
C JustinC Saipriya

Abstract

In this study, super paramagnetic iron oxide nanoparticles (SPIONs) were produced by chemical co-precipitation method, then it was constructed to be a core shell nanoparticle by functionalizing with SDS, loading with curcumin and coating with a biopolymer i.e. chitosan. Each step was analyzed microscopically and spectroscopically. The produced coreshell particles were between 40 and 45nm and these coreshell particles were utilized for drug delivery studies against cervical cancer cell line-HeLa cells. The coreshell SPIONs were found to be releasing curcumin in between 6 and 12 h, which was evidenced by increased apoptotic cells and increased caspase 3 expression in HeLa cells.

References

Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·H MaedaK Hori
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·H MaedaT Konno
Jan 5, 2002·Journal of Biomedical Materials Research·Pamela J VandeVordPaul H Wooley
Jul 6, 2002·Critical Reviews in Oncology/hematology·Bert HildebrandtHanno Riess
Aug 16, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J van der Zee
Mar 4, 2003·Nature Reviews. Drug Discovery·J Milton Harris, Robert B Chess
Apr 23, 2003·Angewandte Chemie·I W Hamley
Jul 21, 2006·The Journal of Physical Chemistry. B·Lingyan WangChuan-Jian Zhong
Oct 20, 2007·International Journal of Pharmaceutics·Ajit S NarangDanchen Gao
Nov 26, 2010·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Faruq MohammadChalla S S R Kumar
May 3, 2011·Accounts of Chemical Research·Forrest M Kievit, Miqin Zhang
May 5, 2011·Journal of Visualized Experiments : JoVE·Aja M RiegerDaniel R Barreda
May 16, 2014·The Journal of Physical Chemistry. B·Stefanie KleinCarola Kryschi
May 30, 2014·Expert Opinion on Drug Delivery·Sophie LaurentMorteza Mahmoudi
Jul 17, 2014·Biomaterials·Murali M YallapuSubhash C Chauhan
Aug 1, 2014·Chemistry : a European Journal·Massimiliano MagroFabio Vianello
Oct 5, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·C ScialabbaG Giammona
Dec 4, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kavirayani Indira Priyadarsini
Dec 21, 2016·Cancer Investigation·Alessandro AllegraCaterina Musolino

❮ Previous
Next ❯

Citations

Jan 1, 2020·Nanomaterials·Roxana Cristina PopescuBogdan Stefan Vasile
Jun 7, 2019·IET Nanobiotechnology·Senthilkumar PachiyappanAntony Vincent Samrot
Dec 3, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·J Queiros CamposP Kuzhir
Jan 2, 2022·Scientific Reports·Antony V SamrotS Suresh Kumar

❮ Previous
Next ❯

Methods Mentioned

BETA
AFM
ELISA
flow cytometry

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Zhan-jun LiuHong-guang Dai
Journal of Controlled Release : Official Journal of the Controlled Release Society
Kinam Park
© 2022 Meta ULC. All rights reserved