Preparation, characterization and cytocompatibility of bioactive coatings on porous calcium-silicate-hydrate scaffolds

Materials Science & Engineering. C, Materials for Biological Applications
Alexandra A P Mansur, Herman S Mansur

Abstract

The major goal of this research was to investigate and characterize the deposition of a biomimetic apatite-like coating onto the surface of 3D porous calcium-silicate-hydrate scaffolds with suitable bioactivity for potential application in bone tissue engineering. Basically, Portland cement, water, sand and lime were mixed for preparing the slurry which was poured into molds, and fine aluminum powder was added as foaming agent resulting on the formation of porous 3D structures. After aging for 28days, these porous inorganic scaffolds were immersed in calcium chloride supersaturated solution in PBS for 7days at 37°C for the biomimetic layer deposition. Scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier Transformed Infrared Spectroscopy (FTIR) techniques were used in order to characterize the porous scaffolds and the apatite-like biomimetic coating. The results have showed that 3D constructs were successfully produced with interconnected porosity, compressive strength and cytocompatibility appropriate for potential use as an alternative in trabecular bone repair.

References

Dec 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R Z LeGeros, R G Craig
Feb 28, 2002·Journal of the American Chemical Society·William L Murphy, David J Mooney
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·Susmita BoseAmit Bandyopadhyay
Jun 2, 2005·Biomaterials·Wenyuan ZhaoJiang Chang
Apr 29, 2006·Radiologic Clinics of North America·Francesca D BeamanMark J Kransdorf
Oct 25, 2008·Journal of Materials Science. Materials in Medicine·Alexandra A P Mansur, Herman S Mansur
Nov 14, 2008·Chemical Reviews·Racquel Zapanta LeGeros

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Citations

Nov 29, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Natalia Higuita-CastroDerek J Hansford

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