Preparation of a biocompatible albumin-coated ion exchange resin for bilirubin removal from the blood of jaundiced newborns

Journal of Biomedical Materials Research
S SidemanS Lupovitch

Abstract

Removal of bilirubin by hemoperfusion with ion exchange resin particles is suggested to replace exchange transfusion of blood of jaundiced infants in some cases of unconjugated hyperbilirubinemia. The hemoperfusion system developed here consists of a packed bed of a macroreticular resin which is made biocompatible by a coating of a monomolecular layer of albumin. The choice of the appropriate ionic form of the resin and the proper albumin coating and crosslinking procedure assures a high bilirubin adsorption capacity and excellent blood compatibility of the resin. The albumin coated resin removes in vitro 80-90% of the bilirubin initially present in the plasma. The results encourage in vivo clinical studies.

References

Jan 1, 1976·Biomaterials, Medical Devices, and Artificial Organs·R G MasonS F Mohammad
Apr 1, 1974·Canadian Journal of Physiology and Pharmacology·T M Chang
Jan 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·B T DoumasH G Biggs
Mar 1, 1962·Biophysical Journal·A K SOLOMON

❮ Previous
Next ❯

Citations

Feb 3, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Jian ChenYaoting Yu
Nov 23, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Wenhui ZongYaoting Yu
May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A N CohenC C Webster
May 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J D Ostrow
Nov 30, 2018·Journal of Biomaterials Science. Polymer Edition·Yingda MaLailiang Ou
May 10, 2007·Expert Review of Medical Devices·Marco Morra
Mar 24, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Wenhui ZongJie Shen
Dec 1, 1992·Artificial Organs·T Chandy, C P Sharma
Oct 22, 2008·Journal of the American Chemical Society·Rolf ChelmowskiChristof Wöll
May 1, 1988·Journal of Biomedical Materials Research·R SipehiaT M Chang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biomaterials, Artificial Cells, and Artificial Organs
X X ZhuL E St-Pierre
Journal of Biomedical Materials Research. Part a
Cheng LiMir Imran
© 2021 Meta ULC. All rights reserved