PMID: 7014784Jan 1, 1980Paper

Preparation of a highly purified vaccine against tick-borne encephalitis by continuous flow zonal ultracentrifugation

Journal of Medical Virology
F X HeinzH Fauma

Abstract

By the use of continuous-flow zonal ultracentrifugation, a highly purified, inactivated tick-borne encephalitis (TBE) virus vaccine was prepared tht contained almost exclusively TBE virus particles. The purity of this preparation was 90- to 100-fold higher than that of a previously used partially purified vaccine. A mean protein content of 3-5 microgram/ml in the final vaccine represents 20 mouse protective doses50 in a mouse challenge potency test. This high degree of purity resulted in a strong reduction of side reactions observed with the less purified vaccine.

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Citations

Apr 4, 2001·Journal of Medical Virology·X HanO Vapalahti
Nov 26, 2003·Antiviral Research·Aysegul NalcaChris A Whitehouse
Mar 12, 2003·Vaccine·Christian Kunz
Mar 12, 2003·Vaccine·P Noel BarrettHartmut J Ehrlich
Sep 19, 1998·Clinical and Diagnostic Virology·J Stephenson
May 19, 2004·International Journal of Medical Microbiology : IJMM·Egon MarthSandra Jelovcan
Sep 1, 1996·European Journal of Pediatrics·K WaldvogelD Nadal
Feb 1, 2000·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·F X Heinz
Sep 1, 1999·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·C Schrader, J Süss
Sep 18, 2007·Vaccine·Franz X HeinzMichael Kundi
Sep 18, 2007·Comparative Immunology, Microbiology and Infectious Diseases·Samantha Brandler, Frédéric Tangy
Jan 1, 1991·Contact Dermatitis·W Aberer
Nov 2, 1999·Virology·C SchmaljohnM Bray
Apr 23, 2003·Virology·Helga KroschewskiChristian W Mandl
Apr 1, 1997·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Marta Granström
Oct 13, 2011·Expert Review of Vaccines·Michael W Wolf, Udo Reichl
Oct 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·F X Heinz, C W Mandl
Dec 8, 2005·CNS Drugs·Göran Günther, Mats Haglund

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