Preparation of a macroporous biodegradable polylactide implant for neuronal transplantation

Journal of Biomedical Materials Research
C SchugensG Moonen

Abstract

This article reports the production of a surgical implant meeting several specific requirements such as biocompatibility, biodegradability, macroporosity, and flexibility. Porosity was controlled by an original method consisting of the aggregation of calibrated poly-D,L-lactide microparticles. The size of the interstices between the aggregated microspheres was in a direct relationship to the microsphere diameter. A first approach was based on coating the microspheres with poly(vinyl alcohol) followed by chemically crosslinking the coating layers that were in mutual contact. This method was disregarded because of the acute cytotoxicity of glutaraldehyde used as the crosslinking agent, the absence of macroporosity, and the complete lack of flexibility. A physical technique of aggregation was then tested, which relied on the plasticization of poly-D,L-lactide microspheres with triethylcitrate to the point where microspheres strongly adhered to each other when they were in contact. This method has proved to be straightforward and definitely superior to the chemical approach, particularly with respect to cytotoxicity, control of macroporosity, and flexibility. A polymer support was thus successfully which was biodegradable, macropor...Continue Reading

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Citations

Jun 5, 1999·Journal of Biomedical Materials Research·P X Ma, R Zhang
Oct 18, 2000·Journal of Biomedical Materials Research·T H YoungJ P Hsu
Jan 5, 2002·Journal of Biomedical Materials Research·Hyun D Kim, Robert F Valentini
Feb 9, 2002·Journal of Biomedical Materials Research·Newell R WashburnEric J Amis
Dec 18, 2001·Journal of Biomedical Materials Research·Moriah Nof, Lonnie D Shea
Dec 5, 2006·Journal of Materials Science. Materials in Medicine·F Z CuiI-S Lee
Aug 19, 2007·Journal of Materials Science. Materials in Medicine·Luciana PietroE A R Duek
Apr 12, 2000·Artificial Organs·R M LucianoE A de Rezende Duek
Aug 1, 1998·Journal of Biomaterials Science. Polymer Edition·S WoerlyE Syková
Apr 23, 2013·Journal of Biomedical Materials Research. Part a·Tian-Yi WuYe Huang
Oct 22, 2008·Biomaterials·Christopher B RivesLonnie D Shea
Sep 22, 2007·Biotechnology Advances·In-Yong KimChong-Su Cho
Oct 17, 2008·Journal of Tissue Engineering and Regenerative Medicine·H PeretzR Vago
Apr 23, 2008·Journal of Biomedical Materials Research. Part a·Rahul M Rasal, Douglas E Hirt
Feb 27, 2010·Journal of Biomedical Materials Research. Part a·Jyh-Horng WangTai-Horng Young
Dec 29, 2004·Biomaterials·V M TatardC N Montero-Menei
Dec 18, 2004·Biomaterials·Ming-Hua HoLein-Tuan Hou
Feb 11, 2012·Journal of Bioscience and Bioengineering·Zu-Chian ChiangGuo-Chung Dong
Nov 19, 2003·Journal of Biomedical Materials Research. Part a·Tai-Horng Young, Chih-Huang Hung
Jan 18, 2007·Journal of Biomedical Materials Research. Part a·Po-Chun ChangLein-Tuan Hou
Dec 22, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Rahul M RasalDouglas E Hirt
Jun 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Renyu YangMinglong Yuan

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