Preparation of a mesoporous silica-based nano-vehicle for dual DOX/CPT pH-triggered delivery

Drug Delivery
Maria C LlinàsDavid Sánchez-García

Abstract

A dual doxorubicin/camptothecin (DOX/CPT) pH-triggered drug delivery mesoporous silica nanoparticle (MSN)-based nano-vehicle has been prepared. In this drug-delivery system (DDS), CPT is loaded inside the pores of the MSNs, while DOX is covalently attached to the surface of an aldehyde-functionalized MSN through a dihydrazide-polyethylene glycol chain. Thus, DOX and the linker act as pH-sensitive gatekeeper. The system is versatile and easy to assemble, not requiring the chemical modification of the drugs. While at physiological conditions the release of the drugs is negligible, at acidic pH a burst release of DOX and a gradual release of CPT take place. In vitro cytotoxicity tests have demonstrated that this DDS can deliver efficiently DOX and CPT for combination therapy.

References

Aug 11, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Manish A. Shah, Gary K. Schwartz
Mar 7, 2003·Journal of Medicinal Chemistry·Soobong ParkDuane L Venton
Mar 4, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Matthieu FisichellaMartine Guerin
Mar 12, 2010·Journal of the American Chemical Society·Youqing ShenWilliam J Murdoch
Jul 21, 2010·Nanoscale·Karla K CotíJ Fraser Stoddart
Aug 7, 2010·Small·Juan L Vivero-EscotoVictor S-Y Lin
Sep 15, 2010·Molecular Pharmaceutics·Weiwei GaoOmid C Farokhzad
Sep 6, 2011·Annual Review of Medicine·Andrew Z WangOmid C Farokhzad
Oct 25, 2011·Nanotechnology·Jianquan FanShuizhu Wu
Dec 21, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Elena AznarPedro Amorós
Jan 5, 2012·Chemical Society Reviews·Zongxi LiJeffrey I Zink
Aug 28, 2012·Advanced Drug Delivery Reviews·Veronika MamaevaMika Lindén
Sep 25, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Alessandro AgostiniSalvador Gil
Oct 9, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Wilson X Mai, Huan Meng
Jan 29, 2013·International Journal of Cancer. Journal International Du Cancer·Young-Hoon KimChae-Yong Kim
Feb 1, 2012·ChemistryOpen·Alessandro AgostiniPedro Amorós
Aug 16, 2014·International Journal of Cancer. Journal International Du Cancer·Lisa NonnenmacherKlaus-Michael Debatin
Aug 26, 2014·Journal of Colloid and Interface Science·Faheem MuhammadGuangshan Zhu
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 27, 2015·Chemistry of Materials : a Publication of the American Chemical Society·Qing-Lan LiYing-Wei Yang
Mar 27, 2015·Chemical Communications : Chem Comm·Shengwang ZhouXuezhong Du
Apr 24, 2015·Chemical Society Reviews·Nan Song, Ying-Wei Yang
Apr 30, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kathryn M CamachoSamir Mitragotri
Sep 22, 2015·Molecular Pharmaceutics·Wujun XuVesa-Pekka Lehto
Oct 27, 2015·Biomaterials·Stephen KennedyDavid Mooney
Nov 22, 2015·Advances in Colloid and Interface Science·Yit Lung Khung, Dario Narducci
Dec 19, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Zhengfang TianYufang Zhu
Nov 6, 2015·Nanomaterials·Marina Martínez-CarmonaMaria Vallet-Regí
Nov 7, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guo-Feng LuoXian-Zheng Zhang

❮ Previous
Next ❯

Citations

Jan 30, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Albane BiraultCarole Carcel
Feb 14, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Abid Hussain, Shengrong Guo
Aug 24, 2019·Seminars in Cancer Biology·Abul BarkatFarhan J Ahmed
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Disha N MoholkarKiran D Pawar
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Diedie LiJing Xie
May 1, 2021·Pharmaceutics·Alex N FrickensteinLacey R McNally
Aug 31, 2021·Chemistry : a European Journal·Gabriel Martínez-EdoDavid Sánchez-García
Oct 11, 2021·International Journal of Pharmaceutics·Dnyaneshwar KalyaneRakesh Kumar Tekade

❮ Previous
Next ❯

Methods Mentioned

BETA
confocal microscopy
X-ray
flow cytometry
chemical modification
Transmission electron microscopy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.