Preparation of a small intestinal submucosa modified polypropylene hybrid mesh via a mussel-inspired polydopamine coating for pelvic reconstruction

Journal of Biomaterials Applications
Liangpeng GeRenshu Huang

Abstract

Pelvic organ prolapse (POP) is a serious health issue that affects many adult women. Surgical treatments for POP patients comprise a common strategy in which scaffold materials are used to reconstruct the prolapsed pelvic. However, the existing materials for pelvic reconstruction cannot meet clinical requirements in terms of biocompatibility, mechanics and immunological rejection. To address these concerns, polypropylene (PP) mesh was selected because of its strong mechanical properties. Small intestinal submucosa (SIS) was used to modify the PP mesh via a mussel-inspired polydopamine coating to enhance its biocompatibility. The scanning electron microscopy (SEM) and atomic force microscopy (AFM) results demonstrated that SIS was successfully conjugated on the surface of the PP mesh. Moreover, the cytotoxicity results indicated that the PP mesh and SIS-modified PP mesh were safe to use. Furthermore, in vivo tests demonstrated that the fibroplasia around the implanted site in the SIS-modified PP mesh group was significantly less than the fibroplasia around the PP mesh group. In addition, the immunohistochemistry staining results indicated that the expression of pro-inflammatory macrophages (M1) was substantially lower and that t...Continue Reading

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Citations

Sep 7, 2016·BioMed Research International·Shishu HuangNoureddine Abidi
May 19, 2018·Women's Health·Mélanie Aubé, Le Mai Tu
Aug 23, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guangxiu CaoXiaoming Li
Apr 23, 2019·Current Opinion in Urology·Katerina MackovaJan Deprest
Aug 15, 2020·Regenerative Biomaterials·Pan ZhaoJun Fan
May 13, 2019·ACS Biomaterials Science & Engineering·Yabing DongNingwen Zhu

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Methods Mentioned

BETA
scanning
atomic force microscopy
enzyme-linked immunosorbent assay
AFM
ELISA

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