Preparation of a thick polymer brush layer composed of poly(2-methacryloyloxyethyl phosphorylcholine) by surface-initiated atom transfer radical polymerization and analysis of protein adsorption resistance

Colloids and Surfaces. B, Biointerfaces
Yuuki InoueKazuhiko Ishihara

Abstract

The purpose of this study was to prepare a thick polymer brush layer composed of poly(2-methacryloyloxyethyl phosphorylcholine (MPC)) and assess its resistance to protein adsorption from the dissolved state of poly(MPC) chains in an aqueous condition. The thick poly(MPC) brush layer was prepared through the surface-initiated atom transfer radical polymerization (SI-ATRP) of MPC with a free initiator from an initiator-immobilized substrate at given [Monomer]/[Free initiator] ratios. The ellipsometric thickness of the poly(MPC) brush layers could be controlled by the polymerization degree of the poly(MPC) chains. The thickness of the poly(MPC) brush layer in an aqueous medium was larger than that in air, and this tendency became clearer when the polymerization degree of the poly(MPC) increased. The maximum thickness of the poly(MPC) brush layer in an aqueous medium was around 110 nm. The static air contact angle of the poly(MPC) brush layer in water indicated a reasonably hydrophilic nature, which was independent of the thickness of the poly(MPC) brush layer at the surface. This result occurred because the hydrated state of the poly(MPC) chains is not influenced by the environment surrounding them. Finally, as measured with a qua...Continue Reading

References

Apr 2, 2003·Advances in Colloid and Interface Science·E P K CurrieM A Cohen Stuart
Aug 5, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Wei YangShaoyi Jiang
Jul 9, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Wei YangShaoyi Jiang
Aug 14, 2010·Colloids and Surfaces. B, Biointerfaces·Yuuki Inoue, Kazuhiko Ishihara
Feb 5, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Ai T NguyenHan Zuilhof
Mar 9, 2011·Biomacromolecules·Cesar Rodriguez-EmmeneggerHynek Biederman
Aug 20, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·H JiangJ Shen
Aug 1, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Yuuki InoueKazuhiko Ishihara
Feb 26, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Sho SakataKazuhiko Ishihara
Feb 27, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Sho SakataKazuhiko Ishihara

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Citations

Sep 14, 2016·ACS Applied Materials & Interfaces·Kyoko FukazawaKazuhiko Ishihara
Nov 3, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Sheng-Han ChenKazuhiko Ishihara
Mar 10, 2017·Journal of Biomaterials Science. Polymer Edition·Kazuhiko IshiharaKyoko Fukazawa
Mar 7, 2020·Macromolecular Rapid Communications·Wei SunHong Chen
May 28, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jun LiuJian Ji
Feb 21, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Masayasu TotaniKeiji Tanaka
Jun 28, 2020·Colloids and Surfaces. B, Biointerfaces·Kazuhiko IshiharaKyoko Fukazawa
Apr 14, 2018·ACS Applied Materials & Interfaces·Yuuki InoueKazuhiko Ishihara
Nov 18, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Tatsunori SakamakiAtsushi Takahara
Feb 12, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Gustav Ferrand-Drake Del CastilloAndreas Dahlin

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