Preparation of aminoglycoside-loaded chitosan nanoparticles using dextran sulphate as a counterion

Journal of Microencapsulation
Enxian LuCarmen Popescu

Abstract

To prepare aminoglycoside (AG) (streptomycin, gentamicin and tobramycin) loaded chitosan nanoparticles with high drug incorporation efficiency and test the in vivo oral efficacy of streptomycin (SM) loaded chitosan nanoparticles in a Mycobacterium tuberculosis (TB) chronic infection mouse model. Dextran sulphate (a polyanion) was used to shield the positive charge of AG and increase the drug incorporation in the chitosan nanoparticle. By varying the concentration of each component, the formulation of SM-loaded chitosan nanoparticle was optimized by monitoring the drug incorporation efficacy and particle size. The mechanism of the nanoparticle formation was suggested and the preparation method was applied to two other aminoglycosides (AG): gentamicin (GM) and tobramycin (TM). The resulting nanoparticles were characterized by particle diameter, drug incorporation efficacy, drug loading efficacy and zeta potential. The in vitro drug release from these nanoparticles was carried out in pH 1.2 and pH 7.4 buffer. Preliminary in vivo oral efficacy studies of SM-loaded chitosan nanoparticles was performed in a Mycobacterium tuberculosis (TB) chronic infection mouse model. The optimal concentration of streptomycin (SM)/dextran sulphate/c...Continue Reading

References

May 29, 1998·Infection and Immunity·S L BaldwinI M Orme
Oct 2, 1998·Pharmaceutical Research·L Illum
Feb 18, 1999·Biomaterials·H Onishi, Y Machida
May 1, 1999·Antimicrobial Agents and Chemotherapy·M P Mingeot-Leclercq, P M Tulkens
May 13, 1999·Mayo Clinic Proceedings·R S Edson, C L Terrell
Jul 2, 1999·Antimicrobial Agents and Chemotherapy·L B AdamsR T Mehta
Feb 25, 2000·Audiology & Neuro-otology·A Forge, J Schacht
Jun 6, 2000·Advanced Drug Delivery Reviews·H Chen, R Langer
Aug 23, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·K A JanesM J Alonso
Oct 16, 2001·Antimicrobial Agents and Chemotherapy·M Maurin, D Raoult
Dec 6, 2001·The Journal of Antimicrobial Chemotherapy·J DhillonD Mitchison
Mar 29, 2002·Journal of Pharmaceutical Sciences·Wolfgang Friess, Monika Schlapp
Jul 13, 2002·Journal of Pharmaceutical Sciences·Zengshuan MaLee-Yong Lim
Jan 9, 2004·Infectious Disease Clinics of North America·John Turnidge
Feb 14, 2006·Current Drug Delivery·Rachna RastogiMohammed Aqil
Aug 29, 2007·International Journal of Nanomedicine·Katherine Bowman, Kam W Leong

❮ Previous
Next ❯

Citations

Sep 11, 2012·Journal of Materials Science. Materials in Medicine·J ShilpaC S Paulose
Jan 30, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Wanachat ChaiyasanWaree Tiyaboonchai
May 24, 2012·International Journal of Nanomedicine·Yong-yan BeiQiang Zhang
Aug 24, 2012·International Journal of Nanomedicine·Sharif M AbdelghanyChristopher J Scott
Jan 18, 2011·Expert Opinion on Drug Metabolism & Toxicology·Jing SunArik Dahan
Aug 26, 2010·Journal of Pharmaceutical Sciences·Jing Wen LohLee-Yong Lim
Dec 9, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Thierry Delair
Mar 27, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yang LiuXue-nong Zhang
Jul 31, 2013·Journal of Biomedical Materials Research. Part a·Ehsan AboutalebRassoul Dinarvand
Aug 11, 2015·Carbohydrate Polymers·Arwa Matoug ElwerfalliAmr ElShaer
Sep 21, 2012·Journal of Microencapsulation·Hugo Costa, Ana Grenha
Sep 23, 2014·Journal of Microencapsulation·Atul KolateAmbikanandan Misra
May 8, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Solmaz Maleki DizajKhosro Adibkia
Aug 25, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Qin WangQiang Zhang
Aug 3, 2020·International Journal of Biological Macromolecules·Emilia Alfaro-ViquezJess D Reed
Mar 23, 2019·Molecular Pharmaceutics·Rabeb Mouna DerbaliJeanne Leblond Chain

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.