Preparation of beta-XIIa (Hageman factor fragment) from human plasma

Thrombosis Research
D L TankersleyJ S Finlayson

Abstract

beta-Factor XIIa (beta-XIIa, Mr approximately 30,000) was isolated from human plasma by a procedure which utilized, as an initial step, the adsorption of Factor XII to celite. Activation of Factor XII and subsequent release of beta-XIIa was brought about by the proteolytic action of co-adsorbed kallikrein. Two successive chromatographic procedures were then used to achieve a final purification of 4,420-fold over plasma and an overall field of 2.3 mg of beta-XIIa per liter.

References

Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R C WigginsJ H Griffin
Jan 1, 1979·Seminars in Thrombosis and Hemostasis·J H Griffin, C G Cochrane
Jul 13, 1978·The New England Journal of Medicine·B M AlvingJ S Finlayson
Mar 1, 1976·Thrombosis Research·J Y Chan, H Z Movat
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Jul 8, 1980·Biochemistry·D L TankersleyD D Schroeder
Dec 28, 1964·Annals of the New York Academy of Sciences·B J DAVIS

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Citations

Jul 1, 1992·Biomedical Chromatography : BMC·E Simonianová
Jun 1, 1984·The Journal of Clinical Investigation·A de AgostiniM Schapira
Nov 15, 1986·Thrombosis Research·H NishikadoK Murata
Apr 15, 1986·Thrombosis Research·H NishikadoK Murata
Jan 17, 1984·Biochemistry·D L Tankersley, J S Finlayson

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