Preparation of biodegradable polycaprolactone/poly (ethylene glycol)/polycaprolactone (PCEC) nanoparticles

Drug Delivery
Wenjuan JiaZhiYong Qian

Abstract

Biodegradable polyetherester copolymer (PCL/PEG/PCL, PCEC) was synthesized by ring-opening polymerization of epsilon-caprolactone initiated by poly(ethylene glycol) (PEG). The PCEC nanoparticles were prepared by solvent diffusion method or w/o/w double emulsion method. The obtained particles' morphology was observed on scanning electron microscopy, and the particle size distribution was determined using Malvern laser particle sizer. Bovine serum albumin was used as the model water-soluble protein drug, which was successfully encapsulated in PCEC nanoparticles, the drug release behavior was studied in detail. The hydrolytic degradation behavior of the PCEC nanoparticles was also studied.

References

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Citations

Aug 14, 2012·International Journal of Nanomedicine·Runliang FengGuangxi Zhai
May 17, 2014·Journal of Drug Targeting·Balakumar KrishnamoorthyMarslin Gregory
Feb 25, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Ali EatemadiAbolfazl Akbarzadeh
Aug 12, 2009·International Journal of Pharmaceutics·XiaWei WeiZhiYong Qian
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Jun 22, 2019·Scientific Reports·Sidharth RazdanSutapa Barua
May 17, 2017·Advanced Pharmaceutical Bulletin·Mitra Alami-MilaniMitra Jelvehgari
Feb 2, 2020·Scientific Reports·Nazila JalilzadehHamed Hamishehkar
Sep 13, 2020·International Journal of Pharmaceutics·Kang XiongShaoZhi Fu
Aug 29, 2018·Advanced Drug Delivery Reviews·Hamideh ParhizVladimir R Muzykantov

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