Preparation of biodegradable polylactide microparticles via a biocompatible procedure

Macromolecular Bioscience
R LevatoJ A Planell

Abstract

PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180 µm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques.

References

Jul 22, 1998·Regulatory Toxicology and Pharmacology : RTP·J J ClaryJ A van Velthuijsen
Jul 27, 1999·Journal of Colloid and Interface Science·N WuF J Micale
May 5, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·C BerklandD W Pack
Nov 7, 2003·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Grégoire SchwachRobert Gurny
Dec 21, 2004·Drug Development and Industrial Pharmacy·N ClarkeZ Ramtoola
May 9, 2006·Trends in Biotechnology·Jos Malda, Carmelita G Frondoza
Aug 28, 2007·Journal of Pharmaceutical Sciences·Farahidah Mohamed, Christopher F van der Walle
Mar 29, 2008·International Journal of Pharmaceutics·M A HolgadoM Fernández-Arévalo
Jul 16, 2008·International Journal of Pharmaceutics·Christian Wischke, Steven P Schwendeman
Sep 17, 2009·Journal of Materials Science. Materials in Medicine·F MunarinM C Tanzi
Dec 17, 2009·Biomaterials·Gaëtan J-R DelcroixClaudia N Montero-Menei
Feb 16, 2010·Advanced Drug Delivery Reviews·Rosa M A HernándezJosé Luis Pedraz
Sep 4, 2010·Advanced Materials·Jun Young ChungChristopher M Stafford
Jan 25, 2011·International Journal of Pharmaceutics·Van-Thanh TranMarie-Claire Venier-Julienne
Oct 5, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Tao Zhao, Dong Qiu

❮ Previous
Next ❯

Citations

Apr 29, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Aida BaeloEduard Torrents
Sep 13, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Scott A Irvine, Subbu S Venkatraman
Mar 19, 2014·Annales pharmaceutiques françaises·S BahriS Sfar
Feb 12, 2020·Advanced Materials·Riccardo LevatoJos Malda
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Barbara Blanco-FernandezElisabeth Engel
Nov 6, 2018·Drug Discovery Today·Guillaume BouguéonSylvie Crauste-Manciet
Oct 30, 2020·ACS Applied Materials & Interfaces·Eleana SomvilleKarine Glinel
Jun 20, 2020·Chemical Reviews·Lauren N West-LivingstonJames J Yoo
Sep 9, 2021·ACS Applied Materials & Interfaces·Gerard Rubí-SansElisabeth Engel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.