Preparation of chitosan-ferulic acid conjugate: Structure characterization and in the application of pharmaceuticals

International Journal of Biological Macromolecules
Chen Li, Jian-Bin Li

Abstract

A novel drug delivery system based on chitosan derivatives was prepared by introducting ferulic acid to chitosan adopting a free radical-induced grafting procedure. This paper used an ascorbic acid/hydrogen peroxide redox pair as radical initiator. The chitosan derivative was characterized by Fourier transformed infrared (FTIR), Ultraviolet-visible spectrum (UV), Differential scanning calorimetry (DSC), X-ray diffraction (XRD) and Electron microscopic scanning (SEM). What is more, preparing microcapsules with the chitosan conjugate as wall material, the drug release propertie of chitosan conjugates were compared with that of a blank chitosan, which treated in the same conditions but in the absence of ferulic acid. The study clearly demonstrates that free radical-induced grafting procedure was an effective reaction methods and chitosan-ferulic acid is a potential functionalized carrier material for drug delivery.

Citations

Aug 9, 2020·Journal of Tissue Engineering and Regenerative Medicine·Chien-Ying WangYung-Hsin Cheng
Jun 17, 2020·Journal of the Science of Food and Agriculture·Chun WangJing-Kun Yan
May 31, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Isabela Angeli de LimaRubiana Mara Mainardes
Dec 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nur Afiqah AhmadJun Wei Lim
Apr 10, 2019·Current Medicinal Chemistry·Iolanda Francolini, Antonella Piozzi
Nov 27, 2019·International Journal of Biological Macromolecules·M Gover AntonirajC Anandharamakrishnan
Jan 9, 2021·International Journal of Biological Macromolecules·Darshan R TelangeNilesh R Rarokar

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