Preparation of collagen modified photopolymers: a new type of biodegradable gel for cell growth.

Journal of Materials Science. Materials in Medicine
Gülay BayramoğluAtilla Güngör

Abstract

In this study a new branched methacrylated poly(propylene glycol-co-lactic acid) (PPG-PLA-IEM) and methacrylated cellulose acetate butyrate resin (CAB-IEM) were synthesized. Hydrogels with various amounts of PPG-PLA-IEM and CAB-IEM (25, 50 and 75 wt% IEM modified) were prepared by photopolymerization. Collagen tethered PEG-monoacrylate (PEGMA-collagen) was prepared and introduced as a bioactive moiety to modify the hydrogel in order to enhance cell affinity. In vitro attachment and growth of 3T3 mouse fibroblasts and human umbilical vein endothelial cells (HUVEC) on the hydrogels with and without collagen were also investigated. It was observed that, the collagen improves the cell adhesion onto the hydrogel surface. With the increasing amount of collagen, cell viability increased by 28% for ECV304 (P < 0.05) and 30% for 3T3 (P < 0.05).

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Citations

Feb 9, 2012·Journal of Materials Science. Materials in Medicine·Fan YangChangsheng Liu
Aug 11, 2011·Biotechnology and Bioengineering·Russell Kirk PirloBradley Ringeisen
Aug 4, 2016·ACS Applied Materials & Interfaces·Oleg V ManaenkovLyudmila M Bronstein
Apr 5, 2011·Journal of Biomaterials Science. Polymer Edition·Emrah ÇakmakçıKadriye Akgün Dar
Aug 11, 2011·Macromolecular Bioscience·Charles M Rubert PérezJean Chmielewski
Dec 24, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Labib ZairMarek Ostrowski

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