Preparation of cryoprecipitate from riboflavin and UV light-treated plasma

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
A EttingerRaymond Goodrich

Abstract

The Mirasol® pathogen reduction technology system for plasma is based on a riboflavin and UV light treatment process resulting in pathogen inactivation due to irreversible, photochemically induced damage of nucleic acids. This study was undertaken to evaluate the possibility of making pathogen reduced cryoprecipitate from riboflavin and UV light- treated plasma that meets the quality requirements specified by UK and European guidelines for untreated cryoprecipitate. Cryoprecipitate was made from riboflavin and UV light-treated plasma. Plasma units were thawed over a 20 h period at 4°C, and variable centrifugation settings (from 654 g for 2 min to 5316 g for 6 min) were applied to identify the optimal centrifugation condition. Plasma proteins in cryoprecipitate units were characterized on a STA Compact, Diagnostica STAGO and Siemens BCS analyzer. Neither the centrifugation speed or time appeared to have an effect on the quality of the final cryoprecipitate product; however the initial solubilization of the cryoprecipitate product was found to be easier at the lower centrifugation setting (654 g for 2 min). Cryoprecipitate units prepared from Mirasol-treated plasma demonstrated protein levels that were less than levels in untreat...Continue Reading

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Citations

Jun 29, 2014·British Journal of Anaesthesia·B NascimentoJ H Levy
Feb 27, 2018·Transfusion·Parvez M LokhandwalaAaron A R Tobian
May 24, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·T Burnouf
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Sep 30, 2020·Journal of Medicinal Chemistry·João C S SimõesGeorge Loudos

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