Preparation of Dual-Template Epitope Imprinted Polymers for Targeted Fluorescence Imaging and Targeted Drug Delivery to Pancreatic Cancer BxPC-3 Cells

ACS Applied Materials & Interfaces
Chao JiaYu-Kui Zhang

Abstract

Molecularly imprinted polymers were commonly used for drug delivery. However, single-template molecularly imprinted polymers often fail to achieve both drug delivery and precise targeting. To address this issue, a dual-template molecularly imprinted polymer nanoparticle used for targeted diagnosis and drug delivery for pancreatic cancer BxPC-3 cells (FH-MIPNPs) was prepared. In the FH-MIPNPs, the 71-80 peptide of human fibroblast growth-factor-inducible 14 modified with glucose (Glu-FH) and bleomycin (BLM) were used as templates simultaneously, so that the FH-MIPNPs could load BLM and bind to the BxPC-3 cells, which overexpress human fibroblast growth-factor-inducible 14 (FN14). Targeted imaging experiments in vitro show that the FH-MIPNPs could specifically target BxPC-3 cells and that there is no targeting effect on cells without expression of FN14. In vivo antitumor experiment results demonstrated that the FH-MIPNP-loaded BLM (FH-MIPNPs/BLM) could inhibit the growth of xenografts tumor of BxPC-3 (tumor volume increased to 1.05×), which shows that FH-MIPNPs/BLM had obvious targeted therapeutic effect compared to the other three control groups of BLM, FH-NIPNPs/BLM, and physiological saline (tumor volume increased to 1.5×, 1.6...Continue Reading

References

Dec 11, 2002·Biochemical Pharmacology·Thomas R Gadek, John B Nicholas
Apr 8, 2003·Current Medicinal Chemistry. Anti-cancer Agents·S K SharmaK W Bair
Oct 18, 2005·Advanced Drug Delivery Reviews·David CunliffeCameron Alexander
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Oct 28, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Angshuman Ray ChowdhuriSumanta Kumar Sahu
Dec 23, 2016·ACS Applied Materials & Interfaces·Yanhua LiBo Tang
Feb 12, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Yanmei LiJiang Yuan
Aug 22, 2018·Oncology Letters·Armando De VirgilioAntonio Greco
Oct 27, 2018·Journal of Nanoscience and Nanotechnology·Go-Eun ChoiYoung-Il Jeong
Jan 25, 2019·NPJ Vaccines·Xuan-Yi WangYu-Mei Wen
Jan 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Amrita PaulN D Pradeep Singh

❮ Previous
Next ❯

Citations

Oct 2, 2020·BioTechniques·Zahra El-SchichAnette Gjörloff Wingren
Jan 6, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chao JiaYu-Kui Zhang
Apr 17, 2021·Analytical Methods : Advancing Methods and Applications·Xindi WangQiong Jia
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rui Liu, Alessandro Poma
Aug 14, 2020·Chemical Reviews·Karsten HauptBernadette Tse Sum Bui
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Seyed Javad TorabiErfan Rezvani Ghomi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Analytical and Bioanalytical Chemistry
Peter SpégelStaffan Nilsson
Advances in Experimental Medicine and Biology
Kezban Ulubayram
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Behdokht BahramiMohammad Hojjat-Farsangi
© 2021 Meta ULC. All rights reserved