Preparation of emulsifying wax/glyceryl monooleate nanoparticles and evaluation as a delivery system for repurposing simvastatin in bone regeneration

Drug Development and Industrial Pharmacy
Aaron Eskinazi-BudgeMoses O Oyewumi

Abstract

Simvastatin (Sim) is a widely known drug in the treatment of hyperlipidemia, which has attracted so much attention in bone regeneration due to its potential osteoanabolic effect. However, repurposing of Sim in bone regeneration will require suitable delivery systems that can negate undesirable off-target/side effects. In this study, we have investigated a new lipid nanoparticle (NP) platform that was fabricated using a binary blend of emulsifying wax (Ewax) and glyceryl monooleate (GMO). Using the binary matrix materials, NPs loaded with Sim (0-500 µg/mL) were prepared and showed an average particle size of about 150 nm. NP size stability was dependent on Sim concentration loaded in NPs. The suitability of NPs prepared with the binary matrix materials in Sim delivery for potential application in bone regeneration was supported by biocompatibility in pre-osteoclastic and pre-osteoblastic cells. Additional data demonstrated that biofunctional Sim was released from NPs that facilitated differentiation of osteoblasts (cells that form bones) while inhibiting differentiation of osteoclasts (cells that resorb bones). The overall work demonstrated the preparation of NPs from Ewax/GMO blends and characterization to ascertain potential s...Continue Reading

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Citations

Nov 30, 2019·Nanomedicine·Michael J HillMorteza Mahmoudi
Feb 17, 2019·AAPS PharmSciTech·Tori CzechMoses O Oyewumi
Aug 13, 2020·Drug Delivery and Translational Research·Tori Czech, Moses O Oyewumi
Apr 21, 2021·ACS Biomaterials Science & Engineering·Hui JinJincheng Wang
Aug 28, 2021·International Journal of Molecular Sciences·Gudrun C ThurnerPaul Debbage

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