Preparation of fenofibrate nanoparticles by combined stirred media milling and ultrasonication method

Ultrasonics Sonochemistry
Chetankumar M PatelZ V P Murthy

Abstract

The production of fenofibrate nanoparticles combining stirred media milling and ultrasonication method was investigated in the current work. The fenofibrate drug sample was first wet milled in stirred media mill for different times and subsequently processed by ultrasonication. The effects of ultrasonication time, power on final product particle sizes were studied. The pre milling by stirred media milling was resulted into reduction of comminution resistance of material. Subsequent treatment by ultrasonication produced smaller particles than obtained by stirred media milling alone. The resulting nanoparticles were found to exhibit excellent stability as investigated by particle size, zeta potential, and multiple light scattering measurement techniques. Further, qualities of nanoparticles obtained by combined approach were characterized by TEM and XRD analysis.

References

Jun 15, 2007·Chemical Reviews·Jennifer A DahlJames E Hutchison
Feb 19, 2009·Pharmaceutical Research·Vadym N MochalinYury Gogotsi
Feb 24, 2009·Ultrasonics Sonochemistry·Gérard Eddy PoinernZhong-Tao Jiang
Feb 18, 2011·Drug Development and Industrial Pharmacy·Anagha BhakayRajesh N Dave
Mar 12, 2013·Ultrasonics Sonochemistry·Tarig A HassanShaik Jeelani
Apr 23, 2013·Colloids and Surfaces. B, Biointerfaces·Pradum Pundlikrao IgeSurendra G Gattani

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Citations

Sep 19, 2015·International Journal of Pharmaceutics·Juan DuYancai Wang
Jun 17, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Mohammad AzadEcevit Bilgili
Oct 5, 2019·Therapeutic Delivery·Pankaj A Jadhav, Adhikrao V Yadav
Jul 14, 2017·AAPS PharmSciTech·Raj Kumar, Prem Felix Siril
Jul 26, 2019·Inorganic Chemistry·Anoop K GuptaShaikh M Mobin

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