Preparation of fibril nuclei of beta-amyloid peptides in reverse micelles

Chemical Communications : Chem Comm
Yen-Ling LinJerry C C Chan

Abstract

We report the preparation of protofibrils from oligomeric Aβ40 aggregates, which have been incubated under spatially constrained conditions. The molecular structure of the resultant protofibrils is highly homogeneous, suggesting that the phenomenon of structural polymorphism commonly observed in Aβ40 fibrils may be largely due to multiple nucleation events.

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Citations

Jan 23, 2020·Angewandte Chemie·Pinelopi MoutzouriLyndon Emsley
Jun 6, 2020·Chembiochem : a European Journal of Chemical Biology·Maarten SchledornBeat H Meier
Jan 27, 2019·Journal of Biomolecular NMR·Susanne PenzelBeat H Meier
Mar 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Robert KnitschHellmut Eckert
May 29, 2021·Journal of Magnetic Resonance·Lokeswara Rao PotnuruVipin Agarwal
Jun 26, 2021·Journal of the American Chemical Society·Pinelopi MoutzouriLyndon Emsley
Sep 3, 2021·The Journal of Chemical Physics·Bruno Simões de AlmeidaLyndon Emsley

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Methods Mentioned

BETA
infrared spectroscopy
NMR
dynamic light scattering
dot-blot
size exclusion chromatography

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