PMID: 590938Dec 1, 1977

Preparation of highly purified human somatotropin (growth hormone)

Hoppe-Seyler's Zeitschrift für physiologische Chemie
M Schleyer, K H Voigt

Abstract

A method for preparation of highly purified human somatotropin on large-scale basis is described. Starting from deep-frozen pituitary gland, less time is needed to obtain highly purified hormone than with other published methods for preparation of human somatotropin. The hormone obtained in this fasion is chromatographically and electrophoretically homogeneous; it shows high biological and radioimmunological growth hormone activity and is free of other pituitary hormone activities. The effects of various experimental conditions upon aggregation of somatotropin are critically evaluated.

References

Jun 1, 1976·The Journal of Clinical Endocrinology and Metabolism·H EtzrodtE F Pfeiffer
May 1, 1971·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M SchleyerE F Pfeiffer
Dec 1, 1972·Deutsche medizinische Wochenschrift·K E SchröderE F Pfeiffer
May 1, 1970·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M SchleyerA Hinz
Dec 28, 1964·Annals of the New York Academy of Sciences·B J DAVIS

Citations

Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·E WeberR Martin
Oct 1, 1979·Hoppe-Seyler's Zeitschrift für physiologische Chemie·M Schleyer, K H Voigt
Sep 1, 1982·Hoppe-Seyler's Zeitschrift für physiologische Chemie·M SchleyerK H Voigt
Jul 1, 1981·Hoppe-Seyler's Zeitschrift für physiologische Chemie·M SchleyerE Kley

Related Concepts

Cartilage
Chromatography, DEAE-Cellulose
Molecular Sieve Chromatography
Dose-Response Relationship, Drug
Pituitary Stalk
Recombinant Growth Hormone

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