Preparation of hydrophilic poly(lactic acid) tissue engineering scaffold via (PLA)-(PLA-b-PEG)-(PEG) solution casting and thermal-induced surface structural transformation

Journal of Biomaterials Science. Polymer Edition
Xiaomin ZhuAjun Wan

Abstract

Porous poly(lactic acid) (PLA) tissue engineering scaffolds with a hydrophilic surface assembled by polyethylene glycol aggregations were prepared by the solvent casting/particulate leaching method from (PLA)-(PLA-b-PEG)-(PEG) blend solution, where the PLA-b-PEG block polymer serves as an amphiphilic glue between two phases. A thermal recrystallization process was inserted before leaching to induce a phase separation, which subsequently squeezes out PEG to form a hydrophilic shell. Characterizations of XRD and DSC indicated the composition and mixing states of materials. The water contact angle test qualitatively presented the excellent hydrophilicity compared to the pure PLA or PLA-PEG simple blend scaffold. The scanning electron microscope results confirmed the formation of porous structure of [Formula: see text] pore size, with an observable phase separation on the surface. The scaffold was degraded in PBS at [Formula: see text], and the degradation exhibits a three-stage behavior, which evidenced the amphiphilically glued phase separations.

References

May 5, 1999·Journal of Biomaterials Science. Polymer Edition·M LangS Wang
Jul 13, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kwangsok KimMichael Hadjiargyrou
Nov 10, 2004·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·N A WeirG R Dickson
Aug 24, 2012·Physical Chemistry Chemical Physics : PCCP·Chongyun WangXingguo Li

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Citations

Oct 21, 2016·Journal of Tissue Engineering and Regenerative Medicine·Christian DemitriLuigi Ambrosio
Jan 10, 2018·Journal of Biomedical Materials Research. Part a·Birru BhaskarGwendolen C Reilly
Jul 21, 2021·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Xiaoquan ShiHaohao Ning

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Methods Mentioned

BETA
X-ray
thermal treatment

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