Preparation of konjac glucomannan hydrogels as DNA-controlled release matrix

International Journal of Biological Macromolecules
Xian WenChangsheng Zhao

Abstract

In this study, hydrogels for DNA-controlled release was prepared with konjac glucomannan (KGM), a water-soluble non-ionic polysaccharide, by means of deacetylated reaction and physically cross-linking method under mild conditions. The properties of the KGM hydrogels were analyzed by FTIR spectra and scanning electron microscopy (SEM). The integrality of the released DNA was investigated by circular dichroism (CD). The DNA release kinetics was performed using the DNA-loaded KGM gels in buffer solutions of pH 7.4 at 37+/-0.5 degrees C. Peppas model and Higuchi model were used to analysis the DNA release mechanism; the data indicated that the DNA release can be controlled by changing the preparation conditions and the structure parameters of the gels. This study suggested that the KGM hydrogels have a potential use for advanced controlled release.

References

Mar 12, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nancy J MeilanderRavi V Bellamkonda
Apr 15, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Deborah J Quick, Kristi S Anseth
Dec 18, 2004·Biomaterials·Ki Woo ChunTae Gwan Park
Nov 22, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·K RemautS C De Smedt

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Citations

Jul 28, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carien E BenekeJosias H Hamman
Aug 20, 2011·Drug Development and Industrial Pharmacy·Valence M K NdesendoLeith C R Meyer
Aug 3, 2016·International Journal of Biological Macromolecules·Sudhanshu S Behera, Ramesh C Ray
Oct 28, 2017·International Journal of Molecular Sciences·Dan YangYafeng Zheng
Jun 16, 2017··Mochammad A. AshidiqAji Prasetyaningrum

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