Preparation of magnetic polybutylcyanoacrylate nanospheres encapsulated with aclacinomycin A and its effect on gastric tumor

World Journal of Gastroenterology : WJG
Hong GaoWei Zhang

Abstract

To evaluate the effect of aclacinomycin A-loaded magnetic polybutylcyanoacrylate nanoparticles on gastric tumor growth in vivo and in vitro. Magnetic polybutylcyanoacrylate (PBCA) nanospheres encapsulated with aclacinomycin A (MPNS-ACM) were prepared by interfacial polymerization. Particle size, shape and drug content were examined. Female BABL/c nude mice were implanted with MKN-45 gastric carcinoma tissues subcutaneously to establish human gastric carcinoma model. The mice were randomly divided into 5 groups of 6 each: ACM group (8 mg/kg bm); group of high dosage of MPNS-ACM (8 mg/kg bm); group of low dosage of MPNS-ACM (1.6 mg/kg bm); group of magnetic PBCA nanosphere (MPNS) and control group (normal saline). Magnets (2.5 T) were implanted into the tumor masses in all of the mice one day before the therapy. Above-mentioned drugs were administered intravenously to the mice of every group on the first day and sixth day. When the mice were sacrificed, tumor weight was measured, and the assay of granulocyte- macrophage colony forming-unit (CFU-GM) was performed on semi-solid culture. White blood cell, alanine aminotransferase and creatine were examined. 3-(4-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) was used to...Continue Reading

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Citations

Mar 5, 2015·Journal of Drug Targeting·Shiya GaoYanyu Xiao
Feb 19, 2011·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Alina ShapiraYehuda G Assaraf
Jun 8, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marina A Dobrovolskaia, Scott E McNeil
Jun 3, 2021·International Journal of Molecular Sciences·Li-Ching ChangJen-Tsung Yang

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