Preparation of modified peptides: direct conversion of α-amino acids into β-amino aldehydes

Organic & Biomolecular Chemistry
Carlos J SaavedraRosendo Hernández

Abstract

A direct method for the transformation of α-amino acids into β-amino aldehydes was developed, and applied to the modification of the C-terminal residue of peptides. The method takes place in good yields and under mild conditions. The application of this methodology to the preparation of small peptides with γ-amino alcohol units, which are precursors of analogues of peptaibol antibiotics, is also described.

References

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Citations

Nov 11, 2014·Journal of the American Chemical Society·Jia Jia DongBen L Feringa

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