Preparation of multiparticulate systems for oral delivery of a micronized or nanosized poorly soluble drug

Drug Development and Industrial Pharmacy
Matteo CereaCarlo Vecchio

Abstract

The purpose of the present work was to prepare multiparticulate drug delivery systems for oral administration of a poorly soluble drug such as itraconazole. Multiparticulate systems were prepared by extrusion/spheronization technique using a mix of crospovidone, low viscosity hypromellose, microcrystalline cellulose, micronized drug and water. In order to improve the release performance of the multiparticulate systems, the micronized drug was suspended in water with polysorbate 20 and nanonized by a high-pressure homogenization. The suspension of drug nanoparticles was then spray-dried for enabling an easy handling of the drug and for preventing the over-wetting of the powders during extrusion/spheronization processing. Both multiparticulate units prepared with micronized or nanonized drug showed acceptable disintegrating properties. The nanosizing of micronized drug powder provided a significant improvement of drug dissolution rates of the multiparticulates.

References

Apr 1, 1989·Journal of Microencapsulation·H P Huang, I Ghebre-Sellassie
Oct 1, 1988·The Journal of Pharmacy and Pharmacology·K E FieldenR C Rowe
Dec 1, 1999·Pharmaceutical Development and Technology·A W BasitL F Lacey
Jul 13, 2002·Journal of Pharmaceutical Sciences·Jef PeetersMarcus E Brewster
Feb 21, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Elaine Merisko-LiversidgeEugene R Cooper
Jun 15, 2007·International Journal of Pharmaceutics·Yuancai Dong, Si-Shen Feng
May 30, 2008·Pharmaceutical Research·Mahesh V Chaubal, Carmen Popescu
Sep 6, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A Dukić-OttC Vervaet
Sep 13, 2008·International Journal of Pharmaceutics·Stephen B ShrewsburyPaul S Uster
Mar 31, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Lieven BaertJan Rosier
May 12, 2009·International Journal of Pharmaceutics·Andrej DolencOdon Planinsek
Oct 17, 2009·Drug Development and Industrial Pharmacy·P VerheyenP Kleinebudde
Feb 15, 2011·Advanced Drug Delivery Reviews·Libo WuWiwik Watanabe
Mar 17, 2011·Drug Development and Industrial Pharmacy·Alvaro GoyanesRamón Martínez-Pacheco
Jun 21, 2011·International Journal of Pharmaceutics·S PlakkotB Sulaiman
Jun 28, 2011·AAPS PharmSciTech·Alia A BadawiSami Ahmed Alsammit
Sep 20, 2011·International Journal of Pharmaceutics·Jaime SalazarJan P Möschwitzer
Apr 3, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lei GaoXiang Li
Sep 25, 2012·International Journal of Pharmaceutics·Jan P Möschwitzer
Jan 8, 2013·International Journal of Pharmaceutics·Ana M CerdeiraBruno Gander
Aug 21, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yancai WangDianrui Zhang
Aug 31, 2013·Drug Development and Industrial Pharmacy·Jardin Leleux, Robert O Williams
Nov 29, 2013·Pharmaceutical Development and Technology·Bernard F McDonaldIan W Marison
Apr 1, 2014·International Journal of Pharmaceutics·Annika TuomelaLeena Peltonen
Sep 10, 2014·Journal of Pharmaceutical Sciences·Sumit KumarDiane J Burgess
Jul 25, 2015·Journal of Pharmaceutical Sciences·Aditya Tatavarti, Filippos Kesisoglou
Sep 26, 2015·International Journal of Pharmaceutics·Thanh Huong Hoang ThiMarie-Pierre Flament

❮ Previous
Next ❯

Citations

Nov 25, 2016·Pharmaceutical Development and Technology·Yu XiaWen-Qing Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Andrea Foglio BondaFranco Pattarino
The Journal of Pharmacy and Pharmacology
K Marshall, D Sixsmith
Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
M NakaraniS S Vaghani
© 2022 Meta ULC. All rights reserved