Preparation of novel aza-1,7-annulated indoles and their conversion to potent indolocarbazole kinase inhibitors

Bioorganic & Medicinal Chemistry Letters
Rima S Al-awarFaming Zhang

Abstract

The synthesis of novel aza-1,7-annulated indoles was achieved and these were converted to indolocarbazoles that proved to be potent kinase inhibitors. These compounds were also evaluated in a human colon carcinoma cell line and proved to be good antiproliferative agents.

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May 20, 2004·Bioorganic & Medicinal Chemistry Letters·Rima S Al-awarSajan Joseph

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Citations

Apr 7, 2012·Chemical Reviews·Arndt W SchmidtHans-Joachim Knölker
Nov 23, 2006·Natural Product Reports·César SánchezJosé A Salas
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Jiayi WuShuping Luo
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Apr 11, 2014·Chemical Society Reviews·Giuseppe BartoliMonica Nardi
Dec 12, 2018·The Journal of Organic Chemistry·Suk Hun LeeIn Su Kim

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