Preparation of novel tissue acidosis-responsive chitosan drug nanoparticles: Characterization and in vitro release properties of Ca2+ channel blocker nimodipine drug molecules

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
László JanovákFerenc Bari

Abstract

The pH-responsive intelligent drug release facility of hydrophobically modified chitosan nanoparticles (Chit NPs) (d = 5.2 ± 1.1 nm) was presented in the case of poorly water soluble Ca2+ channel blocker nimodipine (NIMO) drug molecules. The adequate pH-sensitivity, i.e. the suitable drug carrier properties of the initial hydrophilic Chit were achieved by reductive amination of Chit with hexanal (C6-) and dodecanal (C12-) aldehydes. The successful modifications of the macromolecule were evidenced via FTIR measurements: the band appearing at 1412 cm-1 (CN stretching in aliphatic amines) in the cases of the hydrophobically modified Chit samples shows that the CN bond successfully formed between the Chit and the aldehydes. Hydrophobization of the polymer unambiguously led to lower water contents with lower intermolecular interactions in the prepared hydrogel matrix: the initial hydrophilic Chit has the highest water content (78.6 wt%) and the increasing hydrophobicity of the polymer resulted in decreasing water content (C6-chit.: 74.2 wt% and C12-chit.: 47.1 wt%). Furthermore, it was established that the length of the side chain of the aldehyde influences the pH-dependent solubility properties of the Chit. Transparent homogenous p...Continue Reading

Citations

Sep 29, 2019·Current Neuropharmacology·Andrew P CarlsonClaude W Shuttleworth
Nov 17, 2020·Frontiers in Neurology·Emily Ross-MunroDavid W Walker
Feb 19, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Carlos A García-GonzálezCarmen Alvarez-Lorenzo
Jun 5, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ayu Pratiwi RumantiGuixue Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Marjan Motiei, Soheila Kashanian
© 2022 Meta ULC. All rights reserved