Preparation of olanzapine and methyl-β-cyclodextrin complexes using a single-step, organic solvent-free supercritical fluid process: An approach to enhance the solubility and dissolution properties

International Journal of Pharmaceutics
Shashi Ravi Suman RudrangiBruce David Alexander

Abstract

The purpose of this study was to evaluate a single-step, organic solvent-free supercritical fluid process for the preparation of olanzapine-methyl-β-cyclodextrin complexes with an express goal to enhance the dissolution properties of olanzapine. The complexes were prepared by supercritical carbon dioxide processing, co-evaporation, freeze drying and physical mixing. The prepared complexes were then analysed by differential scanning calorimetry, X-ray powder diffraction, scanning electron microscopy, solubility and dissolution studies. Computational molecular docking studies were performed to study the formation of molecular inclusion complexation of olanzapine with methyl-β-cyclodextrin. All the binary mixtures of olanzapine with methyl-β-cyclodextrin, except physical mixture, exhibited a faster and greater extent of drug dissolution than the drug alone. Products obtained by the supercritical carbon dioxide processing method exhibited the highest apparent drug dissolution. The characterisation by different analytical techniques suggests complete complexation or amorphisation of olanzapine and methyl-β-cyclodextrin complexes prepared by supercritical carbon dioxide processing method. Therefore, organic solvent-free supercritical...Continue Reading

References

Jan 1, 1975·The Journal of Pharmacy and Pharmacology·K A Khan
Aug 1, 1985·Journal of Pharmaceutical Sciences·B D Anderson, R A Conradi
Nov 5, 1999·Pharmaceutical Science & Technology Today·P York
Apr 28, 2001·Critical Reviews in Therapeutic Drug Carrier Systems·U B Kompella, K Koushik
Jun 1, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·B Pose-VilarnovoJ J Torres-Labandeira
Jul 5, 2001·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A LatrofaG Liso
Jun 8, 2002·International Journal of Pharmaceutics·M CharoenchaitrakoolN R Foster
Sep 29, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Nagesh BandiUday B Kompella
Aug 6, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Elisabeth RodierJacques Fages
Oct 7, 2005·Drug Development and Industrial Pharmacy·Marzia CirriPaola Mura
Dec 24, 2005·Journal of Pharmaceutical Sciences·Ali H Al-MarzouqiAli Dowaidar
Aug 3, 2006·Journal of Pharmaceutical Sciences·Tarja ToropainenKristiina Järvinen
Dec 2, 2006·International Journal of Pharmaceutics·Thorsteinn Loftsson, Dominique Duchêne
Jan 24, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Seoung Wook JunSung-Joo Hwang
Dec 7, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lai Yeng LeeKenneth A Smith
Nov 4, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·P J SalústioH M Cabral Marques
Feb 2, 2012·PDA Journal of Pharmaceutical Science and Technology·Praful Balavant DeshpandeNayanabhirama Udupa
Aug 15, 2012·Chemical Society Reviews·Eric A AppelOren A Scherman
Oct 6, 2012·Pharmaceutical Development and Technology·Priti GirotraKalpana Nagpal
Jul 1, 2009·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Mahmoud El-BadryMohamed Fathy
Aug 1, 2012·Carbohydrate Polymers·Márcia Rocha de FreitasJosé Lamartine Soares-Sobrinho
Jan 13, 2015·International Journal of Pharmaceutics·Shashi Ravi Suman RudrangiStephen Richard Wicks

❮ Previous
Next ❯

Citations

May 11, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Shashi Ravi Suman RudrangiBruce David Alexander
Jul 29, 2017·Advanced Healthcare Materials·Ranjith Kumar KankalaAi-Zheng Chen
Mar 23, 2019·Journal of Biomechanical Engineering·Shan SunMichael Cho
May 21, 2018·Life Sciences·João Gomes Pontes-NetoJosé Lamartine Soares-Sobrinho
Jul 11, 2021·International Journal of Pharmaceutics·D NadarassanD Douroumis
Sep 17, 2021·International Journal of Pharmaceutics·Rahul KumarPranava Chaudhari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

© 2021 Meta ULC. All rights reserved