Preparation of pH-sensitive anionic liposomes designed for drug delivery system (DDS) application

Journal of Oleo Science
Asami AokiMakoto Yuasa

Abstract

We prepared pH-sensitive anionic liposomes composed solely of anionic bilayer membrane components that were designed to promote efficient release of entrapped agents in response to acidic pH. The pH-sensitive anionic liposomes showed high dispersion stability at neutral pH, but the fluidity of the bilayer membrane was enhanced in an acidic environment. These liposomes were rather simple and were composed of dimyristoylphosphatidylcholine (DMPC), an anionic bilayer membrane component, and polyoxyethylene sorbitan monostearate (Tween 80). In particular, the present pH-sensitive anionic liposomes showed higher temporal stability than those of conventional DMPC/DPPC liposomes. We found that pHsensitive properties strongly depended on the molecular structure, pKa value, and amount of an incorporated anionic bilayer membrane component, such as sodium oleate (SO), dimyristoylphosphatidylserine (DMPS), or sodium β-sitosterol sulfate (SS). These results provide an opportunity to manipulate liposomal stability in a pH-dependent manner, which could lead to the formulation of a high performance drug delivery system (DDS).

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Citations

Mar 3, 2020·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kaname HashizakiMakiko Fujii
Dec 19, 2019·Frontiers in Pharmacology·Andreia Borges ScriboniKarina Cogo-Müller
Jul 3, 2020·International Journal of Biological Macromolecules·Avinash Singh PatelPraveen Kumar Sappati

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