Preparation of Rhenium-188-Lipiodol Using Freeze-Dried Kits for Transarterial Radioembolization: An Overview and Experience in a Hospital Radiopharmacy.

Cancer Biotherapy & Radiopharmaceuticals
Edathurutykalarickal Ramakurup RadhakrishnanAjit Shinto

Abstract

Background: Rhenium-188-lipiodol is a clinically effective, economically viable radiopharmaceutical for Selective Internal Radiation Therapy of liver cancer. Present study evaluates the performance of three freeze-dried kits with respect to the radiochemistry, quality control, and overall "ease of preparation" aspects in a hospital radiopharmacy. Materials and Methods: Freeze-dried kits of acetylated 4-hexadecyl-4,7-diaza-1,10-decanedithiol (AHDD), super six sulfur (SSS), and diethyl dithiocarbamate (DEDC), obtained commercially or received as gift, were used for the preparation of Rhenium-188-lipiodol using freshly eluted 188Re-sodium perrhenate from commercial Tungsten-188/Rhenium-188 generator following recommended procedures. Results: The overall yield of Rhenium-188-lipiodol prepared using AHDD Kit, SSS Kit, and DEDC Kit was 74.82% ± 3.3%, 87.55% ± 4.8%, and 76.38% ± 4.6%, respectively. Observed radiochemical purity (RCP) of Rhenium-188-lipiodol prepared using these kits was 88.65% ± 2.8%, 92.92% ± 3.0%, and 91.38% ± 3.0%, respectively. Using a modified version of the DEDC Kits, overall yield of 87.17% ± 2.7% and RCP of 95.43% ± 2.3% could be achieved. Conclusions: While all three freeze-dried kits can be used for the prep...Continue Reading

References

Dec 1, 1992·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·J G LoW K Chan
Mar 1, 1996·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·S J WangF F Knapp
Apr 11, 2001·Nuclear Medicine and Biology·J M JeongM C Lee
Dec 24, 2003·European Journal of Nuclear Medicine and Molecular Imaging·E GarinP Bourguet
Oct 3, 2006·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Yun-Sang LeeYoung-Ger Suh
Aug 19, 2007·International Journal of Radiation Oncology, Biology, Physics·Patricia BernalAjit K Padhy
Nov 26, 2010·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Nicolas LepareurEtienne Garin
Feb 15, 2011·Nuclear Medicine and Biology·Licia UccelliAdriano Duatti
Apr 21, 2012·International Journal of Molecular Imaging·Nicolas LepareurEtienne Garin
Apr 17, 2013·Nuclear Medicine Communications·Alina Lintia-GaultierEric Frampas
Jan 28, 2017·Cancer Biotherapy & Radiopharmaceuticals·Archana MukherjeeAruna Korde
May 10, 2017·Journal of Gastrointestinal Oncology·Olumide B GbolahanMaximilian Pyko
May 10, 2017·Journal of Gastrointestinal Oncology·Eric A WangJeff P Stein
Apr 7, 2018·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Madhava B MalliaAshutosh Dash

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