Preparation of roxithromycin-polymeric microspheres by the emulsion solvent diffusion method for taste masking

International Journal of Pharmaceutics
Yan GaoLi-na Zhang

Abstract

Microspheres of roxithromycin with Eudragit S100 and silica were prepared by the emulsion solvent diffusion method to mask the bitter taste of the antibiotic. The effect of different polymers and drug-polymer ratios on the taste masking and the characteristics of the microspheres were investigated. It was found that Eudragit S100 was the best for masking the unpleasant taste of roxithromycin among the six kinds of polymers investigated. The results of DSC, X-ray diffraction and IR showed that there were several combinations of roxithromycin and Eudragit S100. The influence of other formulation factors, i.e. dichloromethane-acetone ratios and silica-polymer ratios on the properties of the microspheres were also examined. In conclusion, the results of the present study will be helpful for the preparation of oral forms of roxithromycin with an acceptable taste.

References

Dec 1, 1989·British Journal of Clinical Pharmacology·Q Y YueJ Säwe
Oct 16, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·D DuchêneG Ponchel
Feb 13, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·T JaskariJ Hirvonen
Aug 8, 2001·International Journal of Pharmaceutics·T Loftsson, M Masson
Jun 7, 2002·Journal of Pharmaceutical and Biomedical Analysis·Weng NaidongTimothy D J Halls
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·M VuorioK Kontturi

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Citations

Jan 29, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Sanjay ShahSs Agrawal
Jan 29, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Mona Noori KoopaeiRassoul Dinarvand
Nov 20, 2008·AAPS PharmSciTech·Divyakumar BoraKiran Bhise
Aug 6, 2010·Biological & Pharmaceutical Bulletin·Yi-Dong YanHan-Gon Choi
Dec 24, 2008·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Punit P ShahAtul C Badhan
Jun 7, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Vandana KharbSuresh Purohit
Jan 1, 2014·International Scholarly Research Notices·Hemanta Kumar Sharma, Lila Kanta Nath
Dec 18, 2013·Tissue Engineering. Part B, Reviews·Carlos Filipe C JoãoJoão Paulo Borges
Jul 6, 2011·Journal of Microencapsulation·Adeola Adebisi, Barbara R Conway
Dec 8, 2015·Drug Development and Industrial Pharmacy·Vandana KharbSuresh Purohit
Aug 9, 2007·Expert Opinion on Drug Delivery·Dionysios Douroumis
Feb 26, 2010·Drug Development and Industrial Pharmacy·Maryam Maghsoodi, Fatemeh Sadeghpoor
Jun 20, 2008·Journal of Pharmaceutical Sciences·Punit P Shah, Rajashree C Mashru
May 16, 2012·International Journal of Pharmaceutics·Xiujuan LiZhenping Wei
Feb 1, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yvonne PerrieDefang Ouyang
May 5, 2009·International Journal of Pharmaceutics·Zhi-Bing ZhangJimmy Yun
May 6, 2008·International Journal of Pharmaceutics·Jianchen XuKang Zhao
Apr 3, 2008·The Journal of Pharmacy and Pharmacology·Punit P ShahAtul C Badhan
Aug 11, 2011·The Journal of Pharmacy and Pharmacology·Khalida RiziAdrian C Williams
Jul 29, 2015·International Journal of Pharmaceutics·Hideshi NakamuraNoriyuki Namiki
Mar 13, 2014·International Journal of Pharmaceutics·Eun-Jin YiEun-Seok Park
Sep 8, 2016·Drug Development and Industrial Pharmacy·A Michael Rajesh, Kiritkumar Mangaldas Popat
Apr 23, 2010·Chemical & Pharmaceutical Bulletin·Shivsagar Ashok RandaleSanjay Javarilal Surana
Feb 7, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Alberto Diego-TaboadaGrahame Mackenzie
Jan 1, 2014·Journal of Pharmaceutics·Harshal Ashok Pawar, Pooja Rasiklal Joshi
Mar 20, 2014·Jundishapur Journal of Natural Pharmaceutical Products·Mitra JelvehgariFarhad Barghi

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