Preparation of starch nanoparticles in water in oil microemulsion system and their drug delivery properties

Carbohydrate Polymers
Xinge WangXiong Fu

Abstract

In this research, 1-hexadecyl-3-methylimidazolium bromide C16mimBr/butan-1-ol/cyclohexane/water ionic liquid microemulsion was prepared. The effects of n-alkyl alcohols, alkanes, water content and temperature on the properties of microemulsion were studied by dilution experiment. The microregion of microemulsion was identified by pseudo-ternary phase diagram and conductivity measurement. Then starch nanoparticles were prepared by water in oil (W/O) microemulsion-cross-linking methods with C16mimBr as surfactant. Starch nanoparticles with a mean diameter of 94.3nm and narrow size distribution (SD=3.3) were confirmed by dynamic light scattering (DLS). Scanning electron microscope (SEM) data revealed that starch nanoparticles were spherical granules with the size about 60nm. Moreover the results of Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) demonstrated the formation of cross-linking bonds in starch molecules. Finally, the drug loading and releasing properties of starch nanoparticles were investigated with methylene blue (MB) as drug model. This work may provide an efficient pathway to synthesis starch nanoparticles.

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Citations

Jan 27, 2017·Chemical Reviews·Ksenia S EgorovaValentine P Ananikov
Dec 12, 2018·Future Medicinal Chemistry·Susanna SampaolesiLaura Russo
Jan 15, 2021·Comprehensive Reviews in Food Science and Food Safety·Mengting YuQingjie Sun
Mar 3, 2021·Food Research International·Yun Wang, Genyi Zhang
Aug 14, 2020·International Journal of Biological Macromolecules·Arokia Vijaya Anand MariadossMyeong-Hyeon Wang
Apr 6, 2021·Nano Today·Amit KhuranaKala Kumar Bharani
May 19, 2021·International Journal of Biological Macromolecules·Linqi YunJianbin Li
Jun 19, 2021·International Journal of Biological Macromolecules·Paulo Vitor França LemosJanice Izabel Druzian
Jul 25, 2020·Current Topics in Medicinal Chemistry·Huan-Rong LanShi-Bing Wang
Aug 8, 2018·Ultrasonics Sonochemistry·Lifeng XuXuejun Cui

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