Preparation of superparamagnetic iron oxide/doxorubicin loaded chitosan nanoparticles as a promising glioblastoma theranostic tool

Journal of Cellular Physiology
Leila GholamiReza Kazemi Oskuee

Abstract

Theranostic nanoparticles (NPs) are promising for opening new windows toward personalized disease management. Using a single particle capable of both diagnosis and drug delivery, is the major benefit of such particles. In the present study, chitosan NPs were used as a dual action carrier for doxorubicin (DOX; chemotherapeutic agent) and superparamagnetic iron oxide nanoparticles (SPIONs; imaging agent). SPIONs and DOX were loaded at different concentrations within poly-l-arginine-chitosan-triphosphate matrix (ACSD) using the ionic gelation method. NPs' size were in the range of 184.33 ± 4.4 nm. Drug release analysis of DOX loaded NPs (NP-DOX) showed burst release at pH 5.5 (as in tumor environment) and slow release at pH 7.4 (physiological condition), demonstrating pH-sensitive drug release profile. NP-DOX internalization was confirmed by flowcytometry and fluorescent microscopy. Uptake process results were corroborated by accumulation of drug in the intracellular space. Iron content was evaluated by inductively coupled plasma and prussian blue staining. In vitro magnetic resonance imaging (MRI) showed a decline in T 2 relaxation times by increasing iron concentration. MRI analysis also confirmed uptake of NPs at the optimum co...Continue Reading

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Aug 14, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Steven ZanganehMorteza Mahmoudi
Jan 31, 2020·Neurochemical Research·Arundhati JoshiRalf Dringen
Dec 5, 2020·International Journal of Biological Macromolecules·Masoumeh EslahiBahman Yousefi
Jun 3, 2021·Antibiotics·Anbazhagan SathiyaseelanMyeong-Hyeon Wang
Dec 5, 2021·AAPS PharmSciTech·Nkafu Bechem NdemazieEdward Agyare
Jan 11, 2022·Nanomedicine·Dhruba DharJyotirmoy Chatterjee

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