Preparation of synthetic polyoxazoline based carrier and Vibrio cholerae O-specific polysaccharide conjugate vaccine

European Journal of Medicinal Chemistry
Pavol FarkašSlavomír Bystrický

Abstract

Multiple chemical attachments of carbohydrate antigens to linear polymer represent promising technique for creating biologically effective conjugates. A novel conjugate consisting of detoxified lipopolysaccharide of Vibrio cholerae O135, linear polymer (polyoxazoline copolymer, serving as a matrix) and BSA (as immunogenic protein), has been prepared. The reaction conditions were optimized for obtaining high degree of conjugation. Analytical methods were evaluated to characterize conjugates obtained. Proposed chemistry is suitable for preparation of multivalent glycoconjugates in general.

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Aug 6, 2002·European Journal of Medicinal Chemistry·Eva MachováGrigorij Kogan
Jun 1, 2006·Clinical and Experimental Immunology·E PaulovicováS Bystrický
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Citations

Dec 4, 2009·Journal of Materials Science. Materials in Medicine·J KronekI Janigová
May 24, 2011·Journal of Materials Science. Materials in Medicine·Juraj KronekBarbara Mendrek
Mar 30, 2012·Journal of Materials Science. Materials in Medicine·Juraj KronekJozef Lustoň
Apr 16, 2017·European Journal of Medicinal Chemistry·Xin MengTao Zhu
Oct 25, 2017·Scandinavian Journal of Immunology·A Fleischhackerová-SlimákováS Bystrický
Aug 7, 2012·Macromolecular Rapid Communications·Robert LuxenhoferRainer Jordan
Oct 21, 2016·Physiological Research·G MuŽíková, R Laga
Jul 4, 2018·Scientific Reports·Alice Rita SalgarellaLeonardo Ricotti
Aug 31, 2021·Drug Discovery Today·Karin M Torres-ObrequeCarlota O Rangel-Yagui

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