Preparation of Thermoresponsive Polymer Nanogels of Oligo(Ethylene Glycol) Diacrylate-Methacrylic Acid and Their Property Characterization

Nanoscale Research Letters
Hongyan CaoXiang Zheng Kong

Abstract

Stimuli-responsive polymers have received growing attention in recent years owing to their wide applications in diverse fields. A novel stimuli-responsive polymer, based on oligo(ethylene glycol) diacrylate (OEGDA) and methacrylic acid (MAA), P(OEGDA-MAA), is prepared by precipitation polymerization and is shown to have a LCST-type VPTT (volume phase transition temperature) at 33 °C in water and a UCST-type VPTT at 43 °C in ethanol, all at concentration of 1 mg/mL. Both VPTTs are strongly concentration and pH dependent, providing an easy way to tune the phase transition temperature. The polymer is characterized with regard to its composition and its morphology in water and in ethanol at different concentration. The two transitions are studied and interpreted based on the results. This work provides a novel way for the preparation of a new type of stimuli-responsive polymer with great potential for different applications, particularly those in biomedical areas because PEG-based stimuli-responsive polymers are known to be nontoxic and non-immunogenic.

References

Oct 5, 2006·Journal of the American Chemical Society·Jean-François LutzAnn Hoth
Jun 2, 2009·Macromolecular Rapid Communications·Xiang Zheng KongLina Zhang
Jul 26, 2011·Advances in Colloid and Interface Science·Yu SamchenkoO Korotych
Mar 1, 2012·Chemical Reviews·Tina VermondenWim E Hennink
Mar 2, 2013·Chemical Society Reviews·Debashish RoyBrent S Sumerlin

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Citations

Sep 30, 2020·Journal of the American Chemical Society·Dorota GrzelakLuis M Liz-Marzán

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Methods Mentioned

BETA
dynamic light scattering

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